BS 150 Seth Grant Explores the Synaptome

Brain Science with Ginger Campbell, MD: Neuroscience for Everyone

Ginger Campbell, MD

Life Sciences, Health & Fitness, Neuroscience, Medicine, Brain, Science

4.8 • 896 Ratings

🗓️ 26 October 2018

⏱️ 61 minutes

🔗️ Recording | iTunes | RSS

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Summary

BS 150 is my 4th interview with Dr. Seth Grant, the molecular biologist who has discovered surprising things about the evolution of the synapse, including the fact that vertebrates have much more complex synapses than invertebrates. In this interview we talk about his latest paper in Neuron in which his team has developed a method for mapping the synapses across the entire mouse brain. This is called a synaptome and reveals that there is surprising diversity depending on which part of the brain is examined. We discuss the implications of this discovery and how it suggests a new theory of how memory works.

Even though this is a follow up to last year's interview (BS 137), Dr. Grant provides all the background that a new listener will need to appreciate his work.

For complete show notes and episode transcripts please visit http://brainsciencepodcast.com.

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Transcript

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0:00.0	Welcome to brain science, the show where we explore how recent discoveries in
0:08.0	neuroscience are helping unravel the mystery of how our brain makes us human. This is episode 150 and I'm your
0:17.2	host Dr. Ginger Campbell. Before I tell you about today's guests I want to
0:21.5	correct a mistake I made in episode 148 when I accidentally
0:26.2	said that October 1st was the deadline for signing up for our trip to Australia. I had misunderstood the instructions from my travel agent.
0:37.0	October 1st was actually the first day that you could put down your deposit.
0:42.0	So there's still plenty of time to sign up.
0:45.6	Today's guest is Dr. Seth Grant from the University of Edinburgh in the UK.
0:51.4	This is his fourth time on brain science, which is a record, but the reason I keep having him back is that he keeps making new mind-blowing discoveries.
1:02.0	When we first talked back in 2008, he introduced us to the evolution
1:07.4	of the synapse and the surprising fact that vertebrates have more proteins in their synapses than in vertebrates.
1:16.0	Today we are going to take that discovery even further as he tells us about a new paper that describes the first ever
1:24.1	synaptone, which is a map of the synapses, and it is the
1:29.1	synaptone of the entire mouse brain.
1:32.8	Don't worry if that sounds esoteric,
1:34.9	because Dr Grant is an excellent science communicator
1:38.8	and no matter what your background,
1:41.2	this will make sense to you by the end of the interview.
1:45.2	As always, you will find complete show notes and episode transcripts at brainscience podcast.
1:51.1	and you can send me feedback at brain science podcast at gmail.com.
1:56.0	Of course I'll be back after the interview to review the key ideas so please listen all the way to the end.
2:09.0	Seth, it is so great to have you back on the show.
	...

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