Breaking Boundaries In HIV Research: Leor Weinberger On Viral Latency & Revolutionary Therapies
Finding Genius Podcast
Richard Jacobs
4.4 • 1K Ratings
🗓️ 4 October 2024
⏱️ 34 minutes
🧾️ Download transcript
Summary
In today's episode, we are honored to be joined by Leor Weinberger, the William and Ute Bowes Distinguished Professor of Virology, director of the Gladstone Center for Cell Circuitry, professor of pharmaceutical chemistry, and professor of biochemistry and biophysics at Gladstone Institutes/University of California, San Francisco. As a world-renowned virologist and quantitative biologist, Leor has made a significant impact in the field of HIV research with his groundbreaking discovery of the HIV virus latency circuit.
Leor's lab studies the fundamental processes of viral biology in the pursuit of developing innovative first-in-class therapies against HIV. They use computational and experimental approaches, including quantitative, single-cell and single-molecule microscopy and mathematical modeling…
Click play to find out:
- How quantitative and theoretical biophysics apply to HIV.
- Why HIV latency has always been a problem with successful treatment.
- What happens when viral loads are lower in the blood of infected individuals.
- When to administer a therapeutic that overcomes barriers to biodistribution.
How are Leor and his team tackling the biggest challenges in human health? Tune in now to learn more about their unique and innovative approach to disrupting the way science is done – and how these discoveries have the potential to change lives!
You can follow along with Leor and his fascinating work with the Gladstone Center for Cell Circuitry here.
Episode also available on Apple Podcast: http://apple.co/30PvU9
Transcript
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| 0:00.0 | Forget frequently asked questions common sense common knowledge or Google how about advice from a real genius |
| 0:06.7 | 95% of people in any profession are good enough to be qualified and licensed 5% go above and beyond they become very good at what they do but only 0.1% are real Jesus. |
| 0:18.0 | Richard Jacobs has made it his life's mission to find them for you. He hunts down and interviews geniuses in every field, sleep |
| 0:25.2 | science, cancer, stem cells, ketogenic diets, and more. Here come the geniuses. This is the |
| 0:31.2 | Finding Genius Podcast. |
| 0:33.0 | The Richard Jacobs. |
| 0:35.0 | Hello, this is Richard Jacobs with the Finding Genius Podcast. |
| 0:42.0 | My guest today is Léor Weinberger, |
| 0:44.0 | he's the director of the Gladstone Center for Cell Circuitary, |
| 0:47.5 | UCSF. |
| 0:48.4 | He's the William and Ute Bowes, a distinguished professor there. |
| 0:51.5 | A way to talk about a novel treatment that slashes HIV up to 10,000 fold and monkeys with a single dose. So it sounds very promising. So welcome. |
| 1:00.0 | Thank you, Richard. Yeah, if you would tell me a bit about your background and how you got to study this in the first place? |
| 1:05.0 | Sure. I grew up in Toronto and Canada and my family was always engineering, focused and science |
| 1:12.2 | focused and I got interested in the sciences at a very early age and we moved down to Washington DC when I was in high school and I became I got exposure to the US system and and went to college in the US and |
| 1:28.0 | understood that you could study many different things which is very different in the |
| 1:32.0 | the Canadian system and so I started off studying biology because I thought |
| 1:35.5 | biology was interesting. Very quickly realized that I that I really had a way of approaching problems. |
| 1:43.9 | It was more like physics and that where my family intellectual |
| 1:48.2 | tradition came from. |
| 1:49.4 | And so I took on physics as a major and went down that path and started studying at the time there were many physicists who were transitioning into biology in the 1990s and I caught that same bug, went to graduate school at Berkeley and studying biophysics, and the particular branch of biophysics that I was studying was theoretical biophysics. There were a few individuals in the |
| 2:16.1 | field who were studying viruses and particularly using models from mathematical biology and epidemiology to apply to viral kinetics inside of patients in HIV patients. |
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