Hi, this is Tom, and in this episode I'm going to be going through Billory Atresia.

And you can find notes at zero to finals.com and in the zero to finals pediatrics book.

And you can find flashcards and questions at members.0 tofinals.com. And at the end of this episode, we'll go

through some questions on biliria-tresia so you can test yourself on what you just heard. So let's

jump straight in. Bilari atresia is a congenital condition where a section of the bile ducts is either narrowed or absent.

The bile ducts transport bile from the liver to the intestines.

Billerubin is conjugated by the liver and excreted in the bile.

When the bile cannot be transported to the intestines for excretion in the

stool, conjugated bilirubin builds up, causing jaundice. Let's go through the presentation.

Billory atresia presents with neonatal jaundice, with yellowing of the skin and the sclera

caused by raised conjugated bilirubin.

Obstructive jaundice also causes symptoms of pale stools, as bile and bilirubin normally gives stalls their dark colour, and the bile

and bilirubin is not reaching the stalls in bilireatresia, and dark urine, as excess bilirubin is

being excreted in the urine, giving it a darker colour.

Physiological jaundice after being born is normal from days 2 to 7 of age.

Physiological jaundice is caused by an increased breakdown and turnover of red blood cells releasing unconjugated bilirubin.

Additionally, the liver in newborn babies is less developed with a slower clearance of

bilirubin.

Features that separate jaundice caused by biliris atresia from physiological jaundice

are that bilary atresia causes persistent jaundice lasting more than 14 days

in term babies and 21 days in premature babies and bilary atresia causes raised conjugated

bilirubin compared with unconjugated bilirubin in physiological jaundice.

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