Beyond LDL-Cholesterol: These Culprits Drive Artery Plaque Build Up

High Intensity Health with Mike Mutzel, MS

Mike Mutzel

Fasting, Nutrition, Autophagy, Ketogenic, Keto, Health & Fitness, Ketodiet, Medicine

4.8 • 1.2K Ratings

🗓️ 19 July 2024

⏱️ 22 minutes

🔗️ Recording | iTunes | RSS

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Summary

For the past 60 years the medical community has obsessively focused on lowering LDL-cholesterol levels…

Research shows these five preventable health conditions make LDL-Cholesterol more likely to cause artery plaque build-up, even if your LDL-Cholesterol levels are low.

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Link to Video and Show Notes: https://bit.ly/3WfpI5R

Research Mentioned:

Zanoni, P., Velagapudi, S., Yalcinkaya, M., Rohrer, L. & Eckardstein, A. von. Endocytosis of lipoproteins. Atherosclerosis 275, 273–295 (2018).

Ference, B. A., Braunwald, E. & Catapano, A. L. The LDL cumulative exposure hypothesis: evidence and practical applications. Nat. Rev. Cardiol. 1–16 (2024) doi:10.1038/s41569-024-01039-5.

Time Stamps:

00:45 LDL's link with atherosclerosis is nuanced.

02:30 Initial damage to the arterial wall makes LDL levels problematic.

03:45 Increases risk of arterial wall damage: elevated blood pressure, insulin resistance/diabetes, smoking/vaping, obesity, elevated blood viscosity, consuming oxidizableoils.

08:40 High LDL and high triglycerides suggest insulin resistance and increased cardiovascular risk.

09:50 Start with diet and exercise together.

11:20 Statins have concerning side effects.

13:15 Plaque formation begins early in life.

13:50 High LDL is found in centenarians.

14:44 Centenarians are metabolically healthy.

15:40 Your liver makes LDL cholesterol.

16:10 Every cell in your body requires cholesterol.

18:00 Diets high in seed oils make your LDL more likely to be oxidized.

20:55 30-50% of people who have heart attacks have optimal serum cholesterol.

Transcript

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0:00.0	So let's talk more about LDL cholesterol and a new theory that is coming to a mainstream medical doctor near you.
0:05.0	The title of this recently published paper that I think is really well done by the way and I'll put links in the description below.
0:11.0	The LDL cumulative exposure hypothesis evidence and
0:14.2	practical applications that was published just in the 4th of July in Nature Reviews
0:18.6	cardiology and what I love about this paper is this main point that I think we need to talk more about the nuances with regards to
0:26.8	the L the L cholesterol as to how it is linked with the process of atherosclerosis or the plaque formation in your major blood vessels and
0:34.7	arteries and how that is, as you know, linked with the pathology of heart disease and strokes
0:40.8	and blood clots and sudden cardiac death and beyond. So essentially what this paper talks about is this
0:48.8	cumulative lifetime exposure to LDL cholesterol and that that, they say in this paper,
0:53.8	the general thesis here is that you want to minimize
0:56.8	or reduce your cumulative lifetime exposure
0:59.7	to atherogenic lipoproproteins,
1:01.6	like the so-called bad or LDL cholesterol because as they speak about
1:06.1	the pathology in this paper I'm going to really simplify this my friends because
1:10.8	LDL oxidation and infiltration in this fatty streaks and these foam cells that are colloquial called
1:18.9	a atherosclototic plaque and so forth get very complex.
1:22.1	There's a whole 65 page paper
1:25.1	that I will also share in the show notes and so forth
1:27.2	that talk about the initiation of the foam cell
1:29.4	and the ld l getting into the vascular endothelial tissue and it becomes trapped and then
1:34.2	modified and then these so-called immune cells known as macrophages in Gulf it and
1:38.5	then initiate this process of this fatty streak and this can lead to a thrombus or a stroke and then plaque
	...

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