Benefits & Risks of Peptide Therapeutics for Physical & Mental Health

Huberman Lab

Scicomm Media

Science, Life Sciences, Health & Fitness

4.9 • 23.3K Ratings

🗓️ 1 April 2024

⏱️ 87 minutes

🔗️ Recording | iTunes | RSS

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Summary

In this episode, I explain the major categories and types of peptides currently in use for therapeutic purposes. I discuss peptides for improving tissue rejuvenation and repair, promoting longevity, improving muscle growth and fat loss, and boosting mood, vitality, and libido. I explain the biology of how these peptides work and both their potential benefits and risks. I also discuss peptide sourcing, dosages, cycling, routes of administration, and how peptides work in combination. This episode will help you better understand the rapidly expanding landscape of peptide therapeutics and how to evaluate if specific peptides might be advantageous towards achieving your physical or mental health goals. For show notes, including referenced articles and additional resources, please visit hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Mateína: https://drinkmateina.com/huberman Levels: https://levels.link/huberman Joovv: https://joovv.com/huberman LMNT: https://drinklmnt.com/huberman Momentous: https://livemomentous.com/huberman Timestamps (00:00:00) Peptides (00:03:20) Sponsors: Mateina, Levels & Joovv (00:07:44) What is a Peptide? (00:12:06) Peptide Sourcing, Lipopolysaccharide (LPS) (00:14:48) Rejuvenation & Tissue Repair: BPC-157, Angiogenesis (00:21:50) BPC-157 & Tissue Injury; Mode of Delivery (00:27:53) BPC-157: Safety, Doses, Cycling, Tumor Risk (00:35:16) Sponsor: AG1 (00:36:43) Tissue Repair: Thymosin Beta-4, TB-500 (00:40:49) Growth & Metabolism: Growth Hormone, IGF-1, Risks (00:45:25) Secretagogues, Sermorelin, Tesamorelin, CJC-1295 (00:52:21) Sponsor: LMNT (00:53:44) Ipamorelin, Hexarelin, GHRP-3, MK-677; Risks & Timing (00:58:69) Peptides for Growth Hormone & IGF-1, Risk; Combinations & Dosing (01:06:12) Longevity: Thymosin Beta-4, Epitalon (Epithalon) (01:12:09) Vitality: Melanotan, PT-141 (Vyleesi), Risks (01:17:21) Vitality: Kisspeptin (01:21:46) Peptides, Potential Benefits, Side-Effects & Risks (01:24:19) Zero-Cost Support, Spotify & Apple Reviews, Sponsors, YouTube Feedback, Momentous, Social Media, Neural Network Newsletter Disclaimer

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0:00.0	Welcome to the Huberman Lab Podcast, where we discuss science and science-based tools for everyday life.
0:06.0	I'm Andrew Huberman and I'm a professor of neurobiology and ophthalmology at Stanford School of Medicine.
0:15.1	Today we are discussing peptides.
0:17.5	Peptides are a topic that's receiving a lot of attention these days, in part because of the excitement about the so-called
0:23.6	G. L. P. 1. A. P. 1 stands for glucagon-like peptides. These are
0:29.8	drugs used to treat type 2 diabetes as well as drugs used to treat obesity.
0:35.0	Today we are not going to discuss the GLP1 analogs.
0:38.0	However, we are going to discuss some of the other peptides that are receiving a lot of attention these days,
0:44.0	including peptides for tissue healing and repair,
0:47.0	as well as peptides that impact longevity and vitality.
0:50.0	Now in principle, any discussion about peptides could be enormously vast and that's because there are so many different kinds of peptides and by the way I will explain what a peptide is in just a few moments.
1:01.0	But for instance, insulin which is involved in regulating our blood
1:04.2	sugar or blood glucose levels is a peptide. Oxytocin which is sometimes
1:08.4	called the love hormone although I wouldn't say that's the best description
1:11.6	of what oxytocin is.
1:12.8	It's a neuropeptide slash hormone that is involved in everything from pair bonding
1:17.4	to socialization, but a bunch of other things as well.
1:20.1	Those are just two examples of peptides that are familiar to most people at least by name and that exist within the tens of thousands if not hundreds of thousands of different peptides that exist within our brain and body.
1:31.6	Today's discussion is going to focus on peptides that are
1:34.8	increasingly being used for therapeutic purposes and I want to point out
1:38.8	something very important about this topic area. First of all it is a topic area for which there is a lot of confusion.
1:46.0	The mere naming of the peptides is confusing. Oftentimes they're referred to simply by virtue of acronyms and numbers like BPC 157 or MK
	...

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