Hello and welcome to the Zero to Finals podcast. My name is Tom and in this episode I'm going

to be talking to you about Beshitz disease. And if you want to follow along with written notes on

this topic, you can follow along at zero to finals.com slash Beshitz or in the rheumatology section

of the Zero to to finals medicine book.

So let's get straight into it.

Besschitz disease is a complex inflammatory condition

and it's characterized by the presence of

recurrent oral or genital ulcers.

And this is the key fact that you should remember for your exams.

It's associated with oral and genital ulcers. And this is the key fact that you should remember for your exams. It's associated with

oral and genital ulcers. It can also cause inflammation in a number of other areas such as the skin,

the gastrointestinal tract, the lungs, blood vessels, muscular skeletal system and central nervous

system. The presentation can vary a lot between patients

and some patients may be only mildly affected, whereas others can be dramatically affected.

There's a link with a particular gene called HLAB 51 and this can be used as a prognostic

indicator of severe disease. So where people

have this gene, they're more likely to have severe disease. We need to talk about the differential

diagnosis of mouth ulcers, because mouth ulcers are a key feature of Bessett's disease. However,

they're also very common in people who don't have

Beshet's disease, and there's a long list of differentials to mouth ulcers.

The most common is simple aptus ulcers, and these are small, round, white-colored ulcers

that are very common in otherwise healthy people.

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