Hey all, welcome back to the Real Life Pharmacology podcast. I'm your host, pharmacist, Derek Christensen.

Thank you for listening today. The drug of the day is azalastine. Before I get into that, I want to remind you to make sure to go check out

real life pharmacology.com. Get your free 31 page PDF on the top 200 drugs. Great little study guide, refresher,

a no-brainer to have, certainly. So simply an email. We'll get you access to that, and

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at real-life pharmacology.com. All right, so let's pick it up with

our drug of the day today, and that is a lasting. Brand name of this medication is Astopro,

and this medication has recently received OTC approval.

So that's over-the-counter approval.

So you may see patients begin to take this medication on their own.

So it's important that you know about it and make sure you can educate them about it if they have any questions.

So mechanistically, this drug's in nasal spray.

And most nasal sprays are typically going to be used for localized symptoms.

There are a few exceptions to that, obviously, like Narcan.

But anyway, mechanistically, Aeselasting is an antihistamine.

So, again, it blocks H-1 receptors and ultimately reduces histamine release and histamine effects.

So histamine, excessive histamine, is associated with allergy symptoms, and, of course, allergic rhinitis. So runny nose associated with allergies. And that is going to be the primary use that you're going to see iselastine used. Now, you may see it for non-allergic rhinitis as well.

So that's a situation in addition to allergies that you may see it used for. It is typically going

to be dosed one or two sprays in each nostril up to twice a day.

And there are a couple different percent solutions.

It's 0.1% and 0.15%.

Most common one I've seen in practice is 0.15%.

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