Hi there, it's Matt here and welcome back to the podcast and welcome back to two things.

First, welcome back to another AMA episode. The response from you folks has been great and we have decided to try and see if we can get at least one AMA every month that we will release and dedicate.

It won't be a replacement for my usual stock standard to a month episodes.

So this will be essentially a bonus third episode that will be arriving every month but the reason that I believe they've been so successful based on the feedback that we've had from you folks is not because of me, it's in spite of me.

And it's the second welcome that I have, which is welcome back to Dr. Ettie Ben Simone, who folks have had so much rightful adoration of.

Ety, welcome back to the show.

Thank you, mad, it's great to be back.

So let's just dive right into it. I know I think you've got lots of questions that I need to try to offer answers to. I will

butcher those answers and then I'll hand it over to you to provide the meaningful answers.

But let's get into it and go for the first question.

So the first question is about a link between poor sleep

quality and Apple E4 carriers. What is that link? Oh great great question and it's

relevant for us because we've been doing a lot of work in this area of sleep

aging and Alzheimer's disease gosh it was one of the first things that I started

researching. Kof Kof 20 years ago as a... Went by very fast. Yeah as a young PhD student, but it's a great question and it is very relevant because I know that now the rise of all of these different consumer genetic tests have really exploded.

A lot of people, if they choose to, will know what's called their apoe status.

So let me see if I can unfold this in a somewhat structured way. We'll start with what is Apo E4

Genotype. You can think of the Apo E4 genotype as a unique, almost a tag or a label in your body's instructional manual and when I say

instructional manual what I mean is that your DNA is your instruction manual and nested in there is this unique tag.

And this label is specifically coding for a protein named Apo Lipoprotein E, which is, it's almost a little bit like a delivery truck in your body that transports

fats, which is what we call lipids to different places different regions.

Everyone has a two copy version of the apo e gene and they have different numbers. Those numbers run from 2 to 4. And there are varied, therefore,

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