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High Intensity Health with Mike Mutzel, MS

Arthritis is a Metabolic Disease: Beyond the Wear and Tear Paradigm

High Intensity Health with Mike Mutzel, MS

Mike Mutzel

Fasting, Nutrition, Autophagy, Ketogenic, Keto, Health & Fitness, Ketodiet, Medicine

4.81.2K Ratings

🗓️ 25 April 2024

⏱️ 11 minutes

🧾️ Download transcript

Summary

Arthritis isn't just about wear and tear of the joints; it's now being seen as a metabolic disease, affecting more than just where it hurts. Treating it effectively means considering both joint health and as well as blood sugar and metabolic health.

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Link to Video and Show Notes: https://bit.ly/3QixFF4

Research:

Mobasheri, A. et al. The role of metabolism in the pathogenesis of osteoarthritis. Nat. Rev. Rheumatol.13, 302–311 (2017).

Kong, H., Wang, X.-Q. & Zhang, X.-A. Exercise for Osteoarthritis: A Literature Review of Pathology and Mechanism. Front. Aging Neurosci. 14, 854026 (2022).

Show Notes:


00:00 Osteoarthritis has metabolic origins.

00:30 Exercise and a low carb diet support joint health.

02:20 Exercise more, if you have arthritis.

03:50 Inflammation and body weight are involved in the breakdown of joints.

05:00 Leptin, released from fat tissue, triggers chronic inflammation.

07:05 Glucose and insulin parallel with leptin levels.

08:45 Compress your feeding window.

Transcript

Click on a timestamp to play from that location

0:00.0

Arthritis and joint pain are the leading causes of disability.

0:02.9

And today's show, we're going to talk about the changing landscape when it comes to

0:06.2

managing arthritis, looking at it from my metabolic perspective.

0:09.8

So it's been long recognized that osteoarthritis specifically, which is a subset of arthritis, is common wear and tear.

0:17.0

You overuse your joints over time, so your hips, your elbows, your knees, your low back, and your shoulder start to break down from where and tear the old

0:25.2

thinking goes but the new science is suggesting that this disease

0:29.6

osteoarthritis specifically is has a lot of metabolic origins and in today's show we're going to talk

0:34.7

about some of the research validating this new concept and it turns out that exercise walking, supporting metabolic

0:42.0

health with a low-carb diet, for example,

0:44.4

are some of the best ways to support the health of your joints.

0:48.5

So one of the papers we're going to talk about today is titled

0:51.0

Biomarkers for Austroarthritis Current Status and Future Updates

0:54.8

that was published in Best Practice and Research Clinical Rheumatology.

0:58.6

So as I mentioned the landscape of Arthritic Treatment is changing. The investigators say for many years Austroarthritis was described as a non-inflammatory wear and tear disease

1:07.1

because it was perceived to be a slow-burning disease that typically

1:10.4

develops over a long period of time due to the natural wear and tear in sonovial joints.

1:14.7

However, this wear and tear model falls short of describing

1:18.3

all inflammatory disease mechanisms,

1:20.5

and thus the description is no longer used since it prevented the field

1:24.8

from moving towards more innovative treatment options. The wear and tear

1:28.1

disease concept is also antagonistic to data emerging from recent advances in

1:32.2

our understanding of the crucially important

...

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