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The Dr. Hyman Show

Are Psychedelics The Solution To The Opioid Crisis? with Deborah Mash

The Dr. Hyman Show

Dr. Mark Hyman

Health & Fitness, Nutrition, Medicine

4.6 • 8.7K Ratings

🗓️ 19 October 2022

⏱️ 80 minutes

🧾️ Download transcript

Summary

This episode is brought to you by Cozy Earth, InisdeTracker, and Rupa Health.


If you or a loved one struggle with addiction, this is an episode you’re going to want to listen to. Many of our current pharmaceuticals stem from compounds discovered in plant medicines. And many beneficial plants that were discovered decades ago still have huge potential for changing modern medicine—ibogaine is one of them. Today on The Doctor’s Farmacy, I’m excited to sit down with Dr. Deborah Mash to discuss the use of the African plant ibogaine and its metabolite, noribogaine, in the treatment of addiction and how it could impact the devastating opioid epidemic. 


Dr. Deborah Mash is one of the world's foremost experts on ibogaine. She is the CEO and Founder of DemeRx Inc., a clinical-stage drug development company advancing ibogaine and its active metabolite noribogaine for the treatment of opioid use disorder. DemeRx has partnered with ATAI Life Sciences—a global biotech platform with a special focus on psychedelic medicine—to develop ibogaine for those suffering from opioid use disorder. Building on the extensive human data available around ibogaine, DemeRx and ATAI are conducting a Clinical Phase I/II trial in opioid-dependent patients. This landmark trial will advance screening procedures, dosing guidelines, and best practices for opioid withdrawal management and relapse prevention.  


This episode is brought to you by Cozy Earth, InisdeTracker, and Rupa Health.


Cozy Earth makes the most comfortable, temperature-regulating, and nontoxic sheets on the market. Right now, get 40% off your Cozy Earth sheets. Just head over to cozyearth.com and use code MARK40.


InsideTracker is a personalized health and wellness platform like no other. Right now they’re offering my community 20% off at insidetracker.com/drhyman.


Rupa Health is a place where Functional Medicine practitioners can access more than 2,000 specialty lab tests from over 20 labs like DUTCH, Vibrant America, Genova, and Great Plains. You can check out a free, live demo with a Q&A or create an account at RupaHealth.com.


Here are more details from our interview (audio version / Apple Subscriber version):

  • The long history of ibogaine’s ethnobotanical and ethnopharmacological use (7:01 / 4:10) 
  • The power of ibogaine to reset opioid tolerance and bypass many withdrawal symptoms in a single dose (15:41 / 8:11) 
  • How ibogaine works (20:59 / 14:15) 
  • Using ibogaine to protect against future relapse (26:09 / 19:25) 
  • Efforts to understand the importance of ibogaine’s psychedelic effects (30:05 / 24:54) 
  • Assessing the success rates of recovery and relapse prevention from ibogaine treatment (37:49 / 34:02) 
  • Understanding the underlying drivers of addiction for better recovery and relapse treatment (41:46 / 37:55) 
  • The concept of “psychoplastogens” and turning on synaptic plasticity in the brain (51:44 / 47:52) 
  • Humanity’s relationship to plants and plant medicines (57:25 /  53:34) 
  • Risks associated with and considerations for seeking ibogaine treatment (1:03:24 / 59:37)


Learn more about Dr. Mash’s work at demerx.com.





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Transcript

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0:00.0

Coming up on this episode of the doctor's pharmacy.

0:03.6

Maybe these molecules are so important at a time when society is more difficult.

0:09.5

When people are feeling more isolated, things are too fast, we don't get off the grid enough to allow brain to heal.

0:20.1

Hey everyone, it's Dr. Mark.

0:22.1

I don't think there's anything better than waking up feeling super rested, relaxed, and energized.

0:26.5

When we get high quality sleep, that's the norm. Without it, our simple day-to-day tasks can seem impossible and our health suffers.

0:33.0

That's why I'm always looking for ways to upgrade my sleep routine and bamboo sheet sets from CozyEarth is my new favorite way to get an amazing night's rest.

0:40.1

You might be surprised to learn that many types of bedding out there contain toxins that can off-gas into your air and absorb into your skin.

0:46.3

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0:54.3

Sleep actually impacts every part of our health. It helps us maintain a healthy weight by balancing hormones and blood sugar, provides time to detox our brains, let's our muscles, organs, rest and repair,

1:04.3

but so many of us don't get enough sleep or the right quality of sleep to allow the body to do all these important things.

1:09.9

Better sleep is the cornerstone of better health and is something we all have the power to work on.

1:15.7

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1:22.9

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1:26.9

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1:37.9

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1:39.9

You're unique, which means your health and wellness plans should be unique too.

1:43.9

But it can be tough to optimize your health and nutrition programs because it's often difficult to get the data you need.

1:49.9

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1:55.9

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1:57.9

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2:03.9

They can analyze your blood, your DNA, your lifestyle habits, then give you actionable recommendations to help you meet your health and wellness goals.

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