Hello and welcome to the Zero to Finals podcast.

My name is Tom, and in this episode I'm going to be talking to you about antiphosphorylipid syndrome.

And you can follow along with written notes on this topic at zero definals.com slash antifosphyliid syndrome

or in the rheumatology section of the zero definals medicine book.

So let's get straight into it.

Antifospholipid syndrome is a disorder associated with antifospholipid antibodies.

And this is where the blood becomes prone to clotting.

So the patient is in what we call a hypercoagulable state

or high level of coagulation within the body. The main associations are with thrombosis, so the

development of clots and also with complications in pregnancy, particularly recurrent miscarriages.

Antifospholipid syndrome can occur on its own, or it can be secondary to another autoimmune condition,

particularly systemic lupus erythematosis.

So antifospholipid syndrome and SLE often go hand in hand.

It's associated with antifosphilipid antibodies, and there's three particular ones.

The first that you need to remember is lupus anticoagulant, and the second are anti-cardiolipine

antibodies, and there's a third that's less likely to come up in your exams

called anti-Beta-2 glycoprotein-1 antibodies. These antibodies interfere with coagulation and create a

hyper-coagulable state where the blood is more prone to clotting. So let's go through the associations of antipospholipid syndrome.

The first is venous thrombolimbolism, so d-vane thrombosis or dvetes, and pulmonary embolisms or P.E.

It's also associated with arterial thrombosis, so strokes, myocardial infarction and renal thrombosis.

It's associated with pregnancy-related complications like recurrent miscarriages, stillbirth, and preeclampsia.

There's a very specific skin condition called levido reticularis

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