Hello and welcome to the Zero to Finals podcast.

My name is Tom and in this episode I'm going to be talking to you about

anti-diuretic hormone.

And you can find written notes on this topic at zero to finals.com slash antidiarratic hormone or in the endocrinology

section of the second edition of the zero to finals medicine book.

And you can find flashcards and questions to train your knowledge on this content and

help you remember the information for longer at

members.0 tofinals.com. So let's get straight into it. Antidiarretic hormone, or ADH, is produced in the

hypothalamus and secreted by the posterior pituitary gland. The hypothalamus and pituitary are found towards the

middle of the brain. Antidiarytic hormone is also known as vasopressin. It acts on the collecting

ducks of the nephrons in the kidneys to stimulate water reabsorption from the urine back to the blood.

Diuresis refers to increased urine volume, which increases the fluid loss from the body in the urine.

The overall effect of antidiarric hormone is to reduce diuresis, causing less

urine volume and more fluid retained within the body. Let's talk about the control of antidioretic

hormone.

The hypothalamus and pituitary gland are located in the middle of the brain.

Inside the hypothalamus are the supraoptic nucleus and the paraventricular nucleus, which contains specialized neurosecretary cells that produce antidiotic hormone.

These cells stretch down into the posterior pituitary, where they release antideoric hormone into the

general circulation. The release of antidiarric hormone by the neurosecretary cells is primarily controlled by

two other types of specialized cell.

Osmoreceptors found in the hypothalamus and baroreceptors found in the artery walls, particularly in the carotid sinus in the neck,

and the aortic arch in the chest. Osmoreceptors are found inside the hypothalamus. The osmoreceptors

...