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Science Friday

An Animal’s Size And Its Cancer Risk | Bastetodon, A 30 Million-Year-Old Apex Predator

Science Friday

Science Friday and WNYC Studios

Life Sciences, Wnyc, Science, Earth Sciences, Natural Sciences, Friday

4.55.5K Ratings

🗓️ 4 March 2025

⏱️ 18 minutes

🧾️ Download transcript

Summary

A study finds that Peto’s Paradox, which states that larger animals are no more likely to get cancer than smaller ones, may not hold up. Also, a nearly complete predator skull was found in the Egyptian desert. Its lineage indicates that it was a top carnivore of the age.

Transcript

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0:00.0

Listener supported WNYC Studios.

0:11.9

This is Science Friday.

0:13.8

I'm Flor Lichten.

0:15.2

Today in the podcast, looking for clues to fighting cancer in creatures big and small.

0:21.5

Chickens, for example, have high rates of cancer.

0:23.6

On the other side of the coin, we know that dolphins, for example, have very low rates of cancer.

0:32.0

If you throw a huge party, there's more of a chance of something going haywire than if you host a quiet little

0:38.7

get together with a couple of friends. And it makes sense, right? More people, more chance for chaos.

0:43.8

So it also kind of makes sense that in an organism, a bigger species with more cells might have

0:50.4

more of a chance of something going wrong with one of those cells, like a mutation

0:54.8

leading to cancer. Back in 1977, a British epidemiologist named Richard Pito observed that

1:03.4

that didn't seem to be true. Bigger animals didn't seem to have a greater risk of cancer than

1:08.9

smaller ones. This became known as Pito's Paradox,

1:12.9

and also the source of phrases like, elephants don't get cancer, which side note, elephants do,

1:18.6

in fact, get cancer. Anyway, research published this week in the proceedings of the National Academy of

1:23.1

Sciences takes a new look at Pito's Paradox using an unusual set of data, death reports from zoos around the world.

1:31.1

Joining me now to explain is Dr. Sarah Amund.

1:33.8

She's an associate professor of urology and oncology at Johns Hopkins University Medical School and one of the authors of that paper.

1:41.1

Sarah, welcome to Science Friday.

1:42.9

Thanks so much for having me.

1:46.7

Okay, is Pito's Paradox like a hot topic in cancer circles? The cancer research community is a really big place. But there's certainly

1:52.8

a growing interest in this idea of comparative oncology. So what can we learn about cancer rates

...

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