On today's episode of real-life pharmacology, I'm going to cover amino glycosides.

These are agents that are utilized in the management of bacterial infections.

We'll talk about mechanism of action, side effect, monitoring parameters,

as well as the importance of drug concentrations and how those are important in clinical practice.

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Today I'm going to talk about aminoglycoside antibiotics.

And the two classic examples that I always see, I always hear of being utilized, are

gentimicin and tobramycin.

The mechanism of action with use of these antibiotics is that they block bacterial protein

synthesis and therefore ultimately prevent growth replication of the bacteria.

They bind to the 30s and 50s subunits within the bacteria and like I mentioned it blocks that protein synthesis.

Common uses that you'll see amyneclycosized used for. These are very effective at covering gram-negative bacteria.

So bacteria like E. coli, klepsiella, and other bacteria along those lines.

Another bacteria that can be really, really difficult to treat

that amino glycosides can help with is pseudomonas.

Pseudomonas can be very resistant and be a potential hospital or healthcare-associated infection.

And amino glycosides do give us another tool in the toolkit to try to help manage these infections

when many other antibiotics the bacteria may be resistance to.

So definitely remember that it can be utilized for pseudomonas.

UTIs, urinary tract infections is probably the most common setting I see them utilized in.

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