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Science Friday

Alzheimer’s Research Fraud, Extreme Heat Health, Piping Plovers, Octaglove. July 29, 2022, Part 1

Science Friday

Science Friday and WNYC Studios

Life Sciences, Wnyc, Science, Friday, Natural Sciences

4.46.3K Ratings

🗓️ 29 July 2022

⏱️ 46 minutes

🧾️ Download transcript

Summary

Decades Of Alzheimer’s Research Could Be Based On Fraudulent Data

Alzheimer’s disease is a devastating brain disorder that slowly affects memory and thinking skills. For many people who worry that loved ones may succumb to this disorder, the possibility of research in the field of Alzheimer’s is a balm of hope. However, a massive report from Science Magazine highlights a startling discovery: that decades of Alzheimer’s research are likely based on faulty data. Alzheimer's researchers are grappling with the revelation, and what it means for future research of the disease.

In other science news of the week, scientists have identified pits on the moon that are a comfortable temperature: averaging 63 degrees Fahrenheit. But don’t plan that space vacation yet—research finds that air pollution from space-bound rockets has an exorbitantly high effect on global warming—much more than traditional airplane travel.

Joining guest host Sophie Bushwick to discuss these stories is Maggie Koerth, science writer for FiveThirtyEight based in Minneapolis, Minnesota. They also discuss how childhood vaccinations have dropped dramatically during the COVID pandemic, and why this is likely tied to New York’s first Polio case in nearly a decade.

Higher Temperatures Are Bad For The Body

Across the globe, hundreds of millions of people have been dealing with extreme heat. The three most populated countries in the world—China, India and the United States—have been gripped by heat waves throughout the summer.

Extreme heat isn’t just uncomfortable: it can be deadly, putting strain on the organs and systems that keep us in equilibrium. Heat is especially dangerous for vulnerable populations such as the elderly, pregnant people, and those without access to air conditioning. In the United States, heat is responsible for more deaths than any other type of weather event.

Joining guest host Sophie Bushwick to talk about what high temperatures do to the body, and how we can protect our health and safety in a heat wave is Chris Uejio, associate professor of public health at Florida State University in Tallahassee, Florida.

Protecting Piping Plovers Isn’t A Walk On The Beach

July is nearly through, and so is the piping plover’s nesting season. It's make-or-break time for these small, endangered shorebirds. There are roughly 8,000 piping plovers in the entire world. To put that in context, birders often get really excited to see a rare bird like a snowy owl. But there are about 28,000 snowy owls in the world, three times the number of piping plovers.

Since piping plovers make their nests along the water and out in the open, their chicks are very vulnerable to being gobbled up by predators. And a major reason for their decline in numbers is human development along the beaches, lakes, and rivers where piping plovers lay their eggs.

SciFri radio producer Shoshannah Buxbaum went out to Fort Tilden in Queens, NY to report on a volunteer-run conservation effort along the New York City coastline. And later in the segment, Michigan radio reporter Lester Graham talks with guest host Sophie Bushwick about the unique challenges and triumphs of the piping plovers who nest along the Great Lakes.

This Glove Takes Inspiration From An Octopus’ Arm

Octopuses have more than 2,000 suckers on eight arms, and each one is controlled individually, making these critters incredibly dextrous. So when a team of researchers wondered how to design a glove that could hold onto slippery objects underwater, they turned to octopuses for inspiration. Ultimately, they created something they’re calling an octa-glove. Guest host Sophie Bushwick talks with Michael Bartlett, an assistant professor of mechanical engineering at Virginia Tech, about his team’s engineering, and what they learned from the ambidextrous creatures.

Transcripts for each segment will be available the week after the show airs on sciencefriday.com.

Transcript

Click on a timestamp to play from that location

0:00.0

This is Science Friday. I'm Sophie Bushwick in for IRF later this week. I'm technology editor at

0:06.5

Scientific American and I'm glad to be back on your radios today. A bit later in the hour

0:11.5

We'll talk about how extreme heat affects the human body and will take you on a beach vacation to visit the homes of

0:19.3

piping plovers. But first, Alzheimer's disease is a devastating brain disorder that targets the brain's ability to hold on to memories and thinking skills.

0:28.6

For people worried about their loved ones or themselves getting Alzheimer's, research provides hope that the disease could someday be a thing of the past.

0:37.8

But a massive report from Science Magazine highlights a startling discovery that decades of Alzheimer's research may be based on faulty data.

0:48.0

Researchers are grappling with the revelation and what it means for the future of studying the disease.

0:53.2

Joining me today to talk about this and other science stories of the week is my guest, Maggie Kyrth,

0:59.6

Science Raider for 538 based in Minneapolis, Minnesota. Welcome back to the show Maggie. Thanks for having me.

1:05.8

Let's start with this big story about Alzheimer's written by Charles Piller. What does the story say?

1:12.0

Well, you first off, I want to give a brief recap of this amyloid

1:16.4

hypothesis of Alzheimer's because this is really at the center of what's going on. And the basic idea with this is that this degenerative brain disease happens when something causes a protein called amyloid beta to clump up in the brain kind of like a hairball in your shower drain.

1:33.7

This is an idea that's gotten a ton of attention. It's gotten the bulk of the investment money of the last three decades.

1:39.2

It's basically sucked all the air out of the room in the field of Alzheimer's research.

1:43.4

And that's even though as multiple drugs that were designed to kind of drain out all that amyloid beta build up have really failed to help patients.

1:53.5

So this is something that's not standing by itself. You know when we're looking at this report in science that is showing that there's probably some kind of malfeasance happening.

2:05.1

That's not an isolated issue with this hypothesis. There's also other people who have long thought that maybe this was not a correct understanding of how Alzheimer's works.

2:19.8

Tell us a little more about the protein that's implicated amyloid beta. What is this protein and what does it typically do in the brain?

2:28.0

So this is a protein that can occur when a bigger protein called an amyloid precursor protein gets cleaved in a certain way.

2:35.0

And people are still trying to understand what that precursor protein does in your brain exactly just like they're trying to figure out still what beta amyloid does.

2:45.0

What we do know is that beta amyloid is sticky. There was a blog entry that an organic chemist called Derek Low wrote for science where he really described it as something that was just really hard to work with and synthesize because it's just this gummy thing that sticks to everything.

3:04.0

And we know it's definitely found in these plaque like clumps in the brains of people who've been autopsy after dying from Alzheimer's.

...

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