Welcome back to the podcast, Real Life Pharmacology.

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So today I'm going to cover aldosterone antagonists.

And this class of medication, you can, I guess, highlight it under a few different things.

It's anti-hypertensive.

It does lower blood pressure. Honestly,

I don't see it use there a lot because we've got a lot of other medications. It's also classified

as a potassium sparing diuretic. And I'll get into indications and, of course, adverse reactions

and monitoring parameters and all that good

stuff. So let's start off with the mechanism of action and the two drugs that we're going to

really focus on that are aldosterone antagonist. First drug, Spironal Actone, brand name is Lactone. Definitely a common one,

good one to remember. The other one is zyprinone, which is inspra. Honestly, I don't see that one

very often. It's typically much more expensive than spirinal lactone. So I think that's why we tend to see spirinalactone

used a little bit more often, plus probably comfort level with clinicians. They get used to using

what they are used to using. So mechanistically, the mechanism of action with this class of medication,

they really increase water excretion as well as sodium.

So low sodium can happen,

as well as obviously we can set up a type of dehydration situation

if we run off too much fluid.

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