Today, I am blessed to have here with me Alan Cash. He serves as founder and chief science officer at Terra Biological. Join my upcoming FREE keto LIVE training here: http://www.ketosismasterclass.com Researching into the molecular and genomic mechanisms of aging and the effects of calorie restriction on aging, Mr. Cash developed unique molecular methods and compounds to mimic calorie restriction and extend lifespan in laboratory animals. Mr. Cash has an MS in physics from the University of Oklahoma. As an entrepreneur, Mr. Cash has gained recognition and awards from the White House, INC 500 business, Ernst & Young Entrepreneur of the Year, Deloitte and Touche Technology Fast 50, and Top 100 Hotfirm. In this episode, Alan talks about his passion for researching the mechanisms behind aging. During a study, Alan found that oxaloacetate extends the lifespan of worms. He speaks about the other clinical research Alan has done around oxaloacetate and what are the most surprising benefits of this compound. Alan dives into reversing some of the symptoms of premenstrual dysphoric disorder (PMDD), premenstrual syndrome (PMS), and chronic fatigue syndrome. Tune in as we chat about how Alan is researching the effects of oxaloacetate on women with breast cancer. 💊 Purchase Benagene oxaloacetate here: https://bit.ly/3HJLZ44 💊 Purchase Jubilance PMS support here: https://bit.ly/39JJuST / / E P I S O D E S P ON S O R S Biotiquest Sugar Shift product. Regulate glucose, reduce cravings, achieve deeper ketosis, and remove glyphosate. https://biotiquest.com/products/sugar-shift Use the coupon code KAMP10 for 10% off their products. Bioptimizers Masszymes for better digestion on keto and carnivore. Get 10% off your bottle bottle of Masszymes right now by heading to masszymes.com/ketokamp and use coupon code ketokamp10 . Text me the words "Podcast" +1 (786) 364-5002 to be added to my contacts list. [00:45] How Alan Found Out That Oxaloacetate Extends The Lifespan of Worms Alan had a condition that was essentially caused by aging; his problem was fixed through brain surgery. As a physicist, Alan began to wonder why people age. He devised an idea to change the NAD to NADH ratio using oxaloacetate. So, Alan fed worms oxaloacetate to see if they would live longer. It worked! It’s not often you find a way to extend the lifespan of a species. [19:20] Is There Any Concern With Ascorbic Acid and Throwing Off The Copper To Iron Ratio? One hundred fifty milligrams of ascorbic acid is not enough to do anything unless you are very, very sensitive to vitamin C. If you drink a glass of orange juice and feel terrible, you’re probably sensitive to vitamin C. It’s very rare to be sensitive to vitamin C. If you are sensitive to vitamin C, you should not take benaGene. [21:40] The Reason You Should Take Oxaloacetate Every Single Day The best use of oxaloacetate is to use it every day. Oxaloacetate will help with fasting glucose levels and mood issues. When you take oxaloacetate regularly, you can reduce the amount of blood glucose swing throughout the day by 55%. About 10% of the total genes out there change when you calorie restrict. Typically, you will see genomic responses in 30 to 45 days by taking oxaloacetate. [30:05] How Oxaloacetate Can Help With PMS and PMDD Symptoms In the past, we thought that PMS was due to hormonal issues because it happened every month. Well, hormones do help with the timing of things. However, the actual problems seem to be linked to the brain. Women with emotional issues need more glucose in their cerebellum. If you give them glucose, they will feel better. This is why women are reaching for chocolate and carbohydrates. Oxaloacetate converts fatty acids that circulate through your system into glucose. That way, you can make glucose at these times when you need it! During a trial, Alan saw over a 50% reduction in depression and anxiety and a 48% reduction in suicidal ideation by taking oxaloacetate. [38:30] The Most Surprising Benefits Alan Has Seen From Oxaloacetate Alan was surprised to find that oxaloacetate extends the lifespan of worms. As far as inflammation, Alan did some cellular work with oxaloacetate. Oxaloacetate can reduce a significant inflammation pathway in your body. Alan’s customers have reported that oxaloacetate helped them with chronic fatigue syndrome. Within six weeks, the average reduction in fatigue was 25 to 30%. That’s life-changing! [51:30] Could Oxaloacetate Help People With Breast Cancer? In cancer cells, when we increase the levels of oxaloacetate, it reverses the Warburg Effect. The Warburg Effect is where solid cancers take in much more glucose into their cells. They burn that glucose, not in the mitochondria but fermented in the cell’s cytosol. The Warburg Effect makes tumors grow faster but makes them more lethal. Alan is in the middle of a clinical trial on patients with breast cancer and how oxaloacetate can help with their fatigue. AND MUCH MORE! Studies & References on Oxaloacetate. https://pubmed.ncbi.nlm.nih.gov/21092938/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073356/pdf/ogs-63-195.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073356/pdf/ogs-63-195.pdf Oxaloacetate reduces PMS depression, anxiety and suicidal Ideation https://pubmed.ncbi.nlm.nih.gov/35764955/ Oxaloacetate reduces mental and physical fatigue in Chronic Fatigue Syndrome and Long-COVID https://www.dropbox.com/scl/fi/d2xqw1toqbue9zm3i1rqz/IACFS-ME-Presentation-2023-6.0.pptx?rlkey=k6sccxcsvye7dsi3cq075hu1j&dl=0 Interim clinical trial results of the “Restore ME” double blinded placebo-controlled trial presented at the International Association of Chronic Fatigue Syndrome meeting this year (July 2023). https://pubmed.ncbi.nlm.nih.gov/32715609/ Clinical trial in Alzheimer’s patients showing 2,000 mg/day oxaloacetate increased brain glutathione levels and brain neuron glucose uptake Currently we are finishing trials in ALS, Breast Cancer, and Long COVID, and hope to publish the results early next year. Here are some interesting animal studies: https://pubmed.ncbi.nlm.nih.gov/34040085/ Preclinical ALS work https://pubmed.ncbi.nlm.nih.gov/25027327/ Preclinical Alzheimer’s work https://pubmed.ncbi.nlm.nih.gov/34226744/ Inhibition of the Warburg Effect in cancer cells Join my upcoming FREE keto LIVE training here: http://www.ketosismasterclass.com Resources from this episode: Check out Terra Biological LLC: http://terrabiological.com Follow Alan Cash LinkedIn: https://www.linkedin.com/in/alan-cash-014053160/ 💊 Purchase Benagene oxaloacetate here: https://bit.ly/3HJLZ44 💊 Purchase Jubilance PMS support here: https://bit.ly/39JJuST Follow benaGene Facebook: https://www.facebook.com/benaGene1/ Instagram: https://www.instagram.com/benagene1/ Join the Keto Kamp Academy: https://ketokampacademy.com/7-day-trial-a Watch Keto Kamp on YouTube: https://www.youtube.com/channel/UCUh_MOM621MvpW_HLtfkLyQ Get Keto Flex on Audible for Free (New Customers Only): https://adbl.co/36d6A24 Get Keto Flex on Audible here for current customers: https://adbl.co/3699lBm / / E P I S O D E S P ON S O R S Biotiquest Sugar Shift product. Regulate glucose, reduce cravings, achieve deeper ketosis, and remove glyphosate. https://biotiquest.com/products/sugar-shift Use the coupon code KAMP10 for 10% off their products. Bioptimizers Masszymes for better digestion on keto and carnivore. Get 10% off your bottle bottle of Masszymes right now by heading to masszymes.com/ketokamp and use coupon code ketokamp10 . Text me the words "Podcast" +1 (786) 364-5002 to be added to my contacts list. *Some Links Are Affiliates* // F O L L O W ▸ instagram | @thebenazadi | http://bit.ly/2B1NXKW ▸ facebook | /thebenazadi | http://bit.ly/2BVvvW6 ▸ twitter | @thebenazadi http://bit.ly/2USE0so ▸clubhouse | @thebenazadi Disclaimer: This podcast is for information purposes only. Statements and views expressed on this podcast are not medical advice. This podcast including Ben Azadi disclaim responsibility from any possible adverse effects from the use of information contained herein. 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