#838: The Random Show — The 2–2–2 Rule, The Future of AI, Bioelectric Medicine, Surviving Modern Dating, The Promises of DORAs for Alzheimer’s, and Wisdom from Anthony de Mello

The Tim Ferriss Show

Tim Ferriss: Bestselling Author, Human Guinea Pig

Tools Of Titans, Lifestyle Design, Business, Tim Ferriss, Timothy Ferriss Show, Startups, Longform Interviews, Productivity, The 4-hour Workweek, Timothy Ferriss, Tim Ferris, The Tim Ferriss Show, Entrepreneurship

4.6 • 17.7K Ratings

🗓️ 3 December 2025

⏱️ 112 minutes

🔗️ Recording | iTunes | RSS

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Summary

Welcome to another wide-ranging "Random Show" episode that I recorded with my close friend Kevin Rose (digg.com)!

This episode is brought to you by:

Qlosi prescription eye drop used to treat age-related blurry near vision (presbyopia) in adults: https://Qlosi.com/Tim

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Coyote the card game, which I co-created with Exploding Kittens: https://coyotegame.com

Timestamps:

[00:00:00] Start.
[00:00:52] Why Kevin concluded nearly seven months of sobriety, and the 2-2-2 Rule he now follows for alcohol consumption.
[00:07:12] My recent adventures in accelerated TMS and bioelectric medicine.
[00:21:09] The tragic death of Nolan Williams and funding future research through the Saisei Foundation.
[00:24:23] Aphantasia vs. hyperphantasia, and Joshua Waitzkin's ability to "feel" chess.
[00:33:12] DORAs for sleep and Alzheimer's prevention: Matt Walker, Belsomra, and the terrifying p-tau blood test.
[00:41:21] Dale Bredesen's kitchen-sink approach to dementia and the ketogenic connection.
[00:46:22] The rapid pace of AI development: Why your opinion from three months ago is already obsolete.
[00:49:40] Google's full-stack advantage: TPUs, Gemini 3, and why they were built for this moment.
[00:52:50] The future of venture capital: Seed rounds shift later as entrepreneurs gain leverage.
[00:58:05] Kevin's three AI investment buckets: Power, data centers, and bloated companies ripe for automation.
[01:02:05] Holiday gift ideas and recommended reading.
[01:17:41] The Way App and meditation with Zen master Henry Shukman.
[01:21:44] Kevin's AI stack: Nothing earbuds, Sandbar ring, Notion AI, and the NotebookLM podcast hack.
[01:26:58] Oboe.fyi: The AI learning platform and my investment philosophy.
[01:32:09] My new girlfriend, the perils of modern dating apps, and building a communication toolkit.
[01:38:17] Terry Real's relationship wisdom: Why objective reality has no place in an argument.
[01:47:18] Dog updates: Molly, a new puppy, and Toaster on rapamycin.
[01:47:58] Parting thoughts and happy holidays.

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Transcript

Click on a timestamp to play from that location

0:00.0	Kev Kev, good to see you.
0:02.5	Tim Tim, another episode of The Random Show.
0:05.4	Glad to be back.
0:05.9	Another episode of The Random Show.
0:07.0	You look very dashing.
0:08.3	For people who can't see you, you have sort of hair-slicked back jacket with wide-open
0:14.0	lapels reminiscent of a leather jacket.
0:16.9	You look like a leading man from the outsiders, that movie back in the day. You just need like
0:23.2	a cigarette in your pocket and some other goodies. But you're looking good. Looking good. You also
0:29.6	have, as you disclosed to be, your secret weapon nearby an IKEA light that is providing
0:34.7	very seductive shadows and contours on your face.
0:39.3	So, well done.
0:39.8	I think we're both kind of hacking it together today.
0:42.6	Yeah, today has been putting together the box car on the way down the hill in a sense
0:47.8	from an equipment standpoint.
0:49.2	But here we are.
0:50.2	Here we are.
0:50.8	Made it.
0:51.6	Now, you asked me to grab a glass of wine, which I didn't.
0:58.0	I ended up grabbing a glass of gin, Caledonia spirits, Bar Hill gin for anybody who's
1:05.1	curious.
1:05.7	I do like my gin, B-A-R-R-Hill.
	...

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