80. Is it Saturated Fat or Polyunsaturated Fat (PUFA) that’s making you Fat and Unwell? Part 2 with Peter from Hyperlipid

Paul Saladino MD podcast

Paul Saladino, MD

Medicine, Health & Fitness

4.8 • 2.7K Ratings

🗓️ 23 November 2020

⏱️ 118 minutes

🔗️ Recording | iTunes | RSS

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Summary

This stuff is technical but critically important to understanding the possible underlying mechanisms by which excess PUFA may be hurting you. If this is confusing you may want to start with the first episode Peter and I did, all of which are at heartandsoil.co.

Petro Dobromylskyj is a veterinarian, trained at the RVC, London University. He was fortunate enough to intercalate a BSc degree in physiology into his veterinary degree. He was even more fortunate to study under Patrick Wall at UCH, who set me on course to become a veterinary anaesthetist, mostly working on acute pain control. That led to the Certificate then Diploma in Veterinary Anaesthesia and enough publications to allow him to enter the European College of Veterinary Anaesthesia and Analgesia as a de facto founding member. Anaesthesia teaches you a lot. Basic science is combined with the occasional need to act rapidly. Wrong decisions can reward you with catastrophe in seconds. Thinking is mandatory. He stumbled onto nutrition completely by accident. Once you have been taught to think, it's hard to stop.

Time Stamps:

0:14:04 Podcast Begins

0:14:46 Last Episode Recap

0:17:20 Why PUFAs drive obesity

0:22:43 Inappropriate insulin sensitivity

0:31:14 Why we have mitochondria

0:41:26 Being right on Q: shaping eukaryotic evolution https://pubmed.ncbi.nlm.nih.gov/27834740/

0:44:14 Mitochondrial satiety signaling

0:50:38 The glycerol phosphate shuttle

1:08:54 Reverse electron transport generating ROS

1:13:58 The Krebs cycle explained

1:22:59 Iatrogenic Hyperinsulinemia, Not Hyperglycemia, Drives Insulin Resistance in Type 1 Diabetes as Revealed by Comparison With GCK-MODY (MODY2) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692813/

1:23:58 Are carbs the root-cause of metabolic dysfunction?

1:30:31 Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase https://www.researchgate.net/publication/262529290_Metformin_suppresses_gluconeogenesis_by_inhibiting_mitochondrial_glycerophosphate_dehydrogenase

1:38:47 Metformin (01) Insulinhttps://high-fat-nutrition.blogspot.com/2017/07/metformin-01-insulin.html

1:44:29 Optimizing satiety with saturated fat and glucose

1:49:50 Where to Find Peter https://high-fat-nutrition.blogspot.com/

1:50:34 The fates of Pyruvate

1:52:02 Diets could

Transcript

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0:00.0	Welcome to the Fundamental Health Podcast. I'm your host, Dr. Paul Saladino. This
0:10.6	podcast is the result of my relentless search to understand and correct the roots of chronic
0:15.1	disease and illness. In this podcast, I will share with you everything I have learned
0:18.9	about how to live the most healthy and radical life possible. Thanks for joining me on this
0:23.4	journey.
0:26.8	That is up you guys. Welcome to another week of the Fundamental Health Podcast. Happy
0:31.3	early Thanksgiving. This has got to be my favorite week of the whole year. I love the fall.
0:39.4	And it's the last week of nose to tail November, which I think is an amazing opportunity just
0:43.6	to remember the bounty of these foods we get to eat and what better week day to spend
0:50.2	time with our families and really recall, reflect and share gratitude for the bounty of nutrition.
0:59.6	So often, I think that what is overlooked in our diets is food quality. I hear more and
1:06.1	more people talking about food mounts and calories and continuous glucose monitors. You
1:11.0	guys know I'm a fan, but even beyond all that, there must be a discussion of food quality
1:19.6	because there are micronutrients in food and no, you cannot get the same quality or even
1:27.0	the same absolute micronutrients with a multivitamin. It just doesn't work that way. Four million
1:33.9	years of hominid evolution did not design us to eat a compressed pill made in a lab in
1:40.5	Costa Mesa, California filled with all kinds of other garbage. It's not bioavailable.
1:46.4	There are no cofactors. The forms of those vitamins are not what we would find in nature
1:51.2	many times. And why would we think this is the way we should be eating vitamins and minerals?
1:56.7	And why do we think that these are all of the vitamins and minerals that we need to thrive
2:00.7	as humans? One of our vitamins and minerals that are found in the nutritious animal foods
2:06.3	that we don't even know about. That's why I'm so interested in things like peptides and
	...

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