Well, hello, hello, guys. You're listening to Beauty Bites with Dr. K, secrets of a plastic surgeon,

and it's time for a podcast. This is going to be a good one.

This is with the amazing Dr. Sandra Kaufman, who is the author of the Kaufman Protocol, right here,

two versions. Here you go. This is version one. I have version two on my bedside table. I'm diving

deep into longevity and all the principles of why we age and how we age. Welcome, Sandra, to the podcast. Oh, it is great to be here. I think we did this a little while back, and it was so much fun. I can't wait to do it again. Yes, this is our second podcast. So those of you who are super fans go back and find the first one. Some things have happened in the year of anti-aging. I want to kind of break this down for

people who are new to the whole longevity space to talk about sort of principles of aging and how you

in your head and in your book also classified like what are what are the hallmarks of aging in terms of

your thinking? How does that differ from the other hallmarks people are talking about? So maybe we could dive

right in. Yeah, absolutely. So you said you wanted to start with hallmarks, right? Yes.

So marks are generally sort of a mishmash list of things that people put together that do in fact

change with age. And there's a bit of a cellular push, but it's not exactly organized, and I think the different

things can be sort of slid around. So what I did, starting about 10 years ago, is I developed what I

call the seven tenants of aging, and it is cell biology as determined by seven different categories.

And very briefly, because I know this could be like, you know, a whole book, conference, right?

But briefly, so a tenant one is things that go awry in your DNA.

And this is, of course, this telemere issues, it's epigenetic modification.

And then the newest thing that I've added into this is chromatin rearrangement.

So there's a sort of a push to understand heterochromatin versus echromatin and what we can do to sort of maintain the appropriate ratios as we age.

But that's tenet one. Tenet two is, of course, mitochondrial failure. You need energy to sort of power

yourselves. Mutantri do a variety of other things as well. But we know that my contendocrity

age for seven very specific reasons, and we can focus on

those. Tenet three is pathways. We talk about the seven mammalian sirtuins, which are histone deacetylases

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