Coming up on today's show.

Your brain cells really have this notion of supply and demand.

It's under so much demand every day, from work stress to environmental stress.

But if you have a lot of supply through ketones and through sleep, through exercise, and through

hydration, then you're going to be able to meet the demands.

If we have no supply, that's when we experience that synaptic loss and that neurodegradation.

So myokines are muscle-based proteins that refer to your muscles as the pharmacies and the myokines as the medications.

And they're just stored in there.

They get released under contraction.

So you can imagine you contract your bicep. They go into

the bloodstream. They have multiple effects on immunity, on cancer, and we can see greater effects

on executive functions. Exercise is fundamentally the most important tool that we have for staving off

Alzheimer's disease. And then it goes to sleep, and then it goes into nutrition.

Everything you do, every choice you make every day is changing your epigenetics.

And with Alzheimer's disease, we know that a strong component is really reliant upon the lifestyle

habits that you engage in every day.

Louisa, you've coined the phrase that what's good for your heart is good for the brain.

Let's start with the connection there.

Yeah, well, look, to be completely honest, when you look at the brain as a whole,

we know it to be the most vascular rich organ in the entire body.

That means that it houses the most amount

of blood vessels per organ in the body, which means it's a hungry organ, right? But how do we get,

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