618: Methylation, Epigenetics & Longevity with Steve Horvath
Age Less / Live More
Lucas Rockwood
4.8 • 1.1K Ratings
🗓️ 1 May 2024
⏱️ 46 minutes
🧾️ Download transcript
Summary
Kane Tanaka of Japan died in 2022 at the age of 119. Lucile Randon of France died in 2023 at 118. Jiroemon Kimura of Japan died in 2023 at 116, the oldest male ever. What did these people have in common? Were they biohackers? Did they do CrossFit? Did they take NAD supplements or run marathons? Nope. Like almost all centenarians they lived exceptionally long lives most-likely due to genetics, combined with a moderately healthy or even average healthy lifestyle. Despite the overwhelming abundance of evidence that we’re all going die sooner rather than later, the quest for longevity never stops. My guest on this week’s podcast has developed a unique way to measure biological age and his work is playing a key role in longevity research and biohacker communities.
Listen and learn:
- The overlooked role of epigenetics in your health and lifespan
- Biohackers, science fiction, and the reality of living a long time
- How methylation patterns can be predictive of lifespan
- The significance of GrimAge for reducing early mortality
Links
ABOUT OUR GUEST
Steve Horvath is a German-American researcher, geneticist, and biostatistician. He is a professor at UCLA and the principal investigator at Altos Labs, specializing in epigenetic biomarkers of aging, genomics, and comparative biology.
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Transcript
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| 0:00.0 | Kane Tanaka of Japan died a couple of years ago at the age of 119. |
| 0:08.0 | Lucille Randen in France died last year at the age of 118 and Giroiman Kimura in Japan died last year at the age of |
| 0:15.9 | 116 he was the oldest male ever recorded women outlive men consistently all |
| 0:21.4 | over the world what are these three recent super centenarians |
| 0:24.9 | have in common? Were they biohackers? Did they do cross-fit? Did they take NAD supplements? Did they run |
| 0:29.4 | marathons? Were they taking Rapomysin or met formin? |
| 0:33.0 | No, none of those things. |
| 0:35.0 | Like almost all centenarians, like almost all super centenarians. |
| 0:39.0 | They lived acceptively long lives, probably due to genetics, |
| 0:42.0 | combined with a moderately healthy or even |
| 0:44.9 | average healthy lifestyle nothing really stands out despite the |
| 0:48.4 | overwhelming abundance that you and I and everybody we're all gonna die |
| 0:51.9 | sooner rather than later in fact the quest for |
| 0:54.6 | longevity never stops and the allure of longevity we can't it never can be squashed my |
| 1:01.7 | guess on this week's podcast developed a unique way |
| 1:04.1 | to measure biological age in contrast to chronological age. |
| 1:07.6 | So how old are your tissues, for example, |
| 1:10.6 | compared to your years on the planet. |
| 1:12.8 | His work is playing a key role in the current longevity research |
| 1:15.8 | and biohacker communities. |
| 1:17.3 | If you're new here, it's the Lucas Rockwood show. |
| 1:19.8 | I'm a yoga teacher and trainer. |
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