Hello and

I'm your host Monica Reinagel

this week's show was suggested by Kelly, who wrote,

My chiropractor is recommending that I switched to a fish oil with pro-resolving mediators, or PRMs.

What are PRMs? Could I buy them separately and take them with the fish oil I'm already

taking? Rather than switching to her more expensive fish oil product, which, unlike the one I'm taking now, is not third-party tested for purity.

Well, one of the things I love about this job is that I am never done learning.

And I have to confess that Kelly's email was the first time I'd ever heard of pro-resolving mediators

but let me fill you in on what I've learned.

But first just a little bit of background to set the stage for this. Fish oil is rich in the omega-3 fatty acids EPA and DHA.

And most American adults don't get the recommended amount of these nutrients from their diet, and a fish oil

supplement is one way to help fill that gap.

Fish oil is also used in higher therapeutic doses to treat and prevent a wide variety of health conditions, including heart disease,

autoimmune disorders, arthritis, and even depression.

There are a few different mechanisms of action here.

Omega-3s are anti-Thrombolicic.

That means that they reduce the tendency of blood

to form clots.

And they're also potent anti-inflammatory's. So how do they do all of this? Well,

omega-3 is are enzymatically converted in your body into various biologically

active molecules and those then orchestrate the body's inflammatory and immune

responses at the cellular level. There are a lot of different types of these active compounds including prostaglandins, icosanoids, and leukotryines.

...