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Sigma Nutrition Radio

#556: Can We Restore the Gut Microbiome Through Dietary Changes? – Anissa Armet, PhD

Sigma Nutrition Radio

Danny Lennon

Nutrition, Health & Fitness

4.8 • 633 Ratings

🗓️ 11 March 2025

⏱️ 66 minutes

🔗️ Recording | iTunes | RSS

🧾️ Download transcript

Summary

There is research suggesting that industrialization has significantly altered the composition of our gut microbiota, with certain microbial species now absent in many industrialized populations.

Given the known associations between gut microbiome diversity and health, researchers have begun investigating whether restoring lost microbial species and adopting dietary patterns similar to those of non-industrialized populations could lead to measurable health benefits.

In a newly-published study, the investigators aimed to explore whether L. reuteri could be successfully reintroduced into the microbiome through the "Restore Diet" and whether such a shift would result in improvements in key cardiometabolic and inflammatory markers.

One of the authors, Dr. Anissa Armet, is on the podcast to discuss this area and both the potential and limitations of microbiome restoration efforts.

Timestamps

  • [03:48] Interview start
  • [08:45] Understanding gut microbiome restoration
  • [11:44] Challenges in microbiome research
  • [21:03] Study design and objectives
  • [43:23] Key findings and results
  • [47:46] Future research directions
  • [01:04:04] Key ideas segment (premium-only)

Links

Transcript

Click on a timestamp to play from that location

0:00.0

Hello and welcome to Sigma Nutrition Radio. This is episode 556 of the podcast. I'm your host,

0:07.1

Danny Lennon. You are very welcome to the show. And today we are going to be discussing the gut microbiome

0:12.8

and in particular questions about whether it is possible and plausible to be able to make

0:18.9

longstanding changes to the gut microbiome through introductions of certain bacterial species.

0:24.6

So this comes about from a variety of different pieces of research over time that have been suggestive of a few things,

0:31.6

from the idea that our gut microbiota has changed over time and that we may have lost certain microbial

0:38.6

species, particularly as we move into more industrialization, and then looking at how there are

0:44.4

certain associations between gut microbiome diversity and health. And so this has led to potential

0:50.6

attempts within research to see, is it possible to restore some of these microbial

0:56.4

species that potentially have benefits that we may have lost or don't have enough abundance

1:02.5

of different types of species?

1:04.7

And see, can they be brought back in through targeted supplementation of those particular

1:10.4

species, but also then

1:11.9

a supportive diet that would allow them to persist. And this is the focus of a newly published

1:18.7

study that the investigators aim to explore whether a particular species, lactobacillus riteary,

1:25.7

could be successfully reintroduced into the gut microbiome

1:29.3

with the aid of something they referred to as the Restore Diet, and seeing whether this shift

1:35.0

not only would lead to certain changes in various cardiometabolic markers, but if this change

1:41.0

was able to persist over time, which is one of these key open questions

1:45.3

that we potentially have in this area.

1:47.9

So to discuss this, today I'm going to be talking with one of the authors, Dr. Anissa Armet,

1:53.3

to highlight not only the specifics of this particular study, but really I think this is a great

...

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