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The Curbsiders Internal Medicine Podcast

#517 DIGEST: Weight regain after weight loss medications, GLP1/GIP comparisons, valacyclovir for Alzheimer’s, and nudges to encourage deprescribing

The Curbsiders Internal Medicine Podcast

The Curbsiders Internal Medicine Podcast

Science, Medicine, Health & Fitness, Education, Higher Education

4.83.3K Ratings

🗓️ 16 March 2026

⏱️ 66 minutes

🧾️ Download transcript

Summary

Join us as we review and appraise recent practice-changing articles. In this episode, we cover the latest in GLP-1s and GIP agonists for CVD, Type 2 Diabetes, and Obesity, valacyclovir to treat Alzheimer’s, weight regain patterns after medication-induced weight loss, and a deep dive into the data behind deprescribing – and behavioral science to increase deprescribing behavior.  Fill your brain hole with a delicious stack of hotcakes! Featuring Paul Williams (@PaulNWilliamz), Alex Chaitoff (@alexchaitoff), Nora Taranto (@norataranto), & Matt Watto (@doctorwatto).

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Credits

  • Written and Hosted by: Nora Taranto MD, MSCE; Alexander Chaitoff MD, MPH; Paul Williams, MD, FACP,, & Matthew Watto MD, FACP
  • Cover Art: Nora Taranto MD, MSCE
  • Reviewer: Sai S Achi MD, MBA, FACP
  • Technical Production: Pod Paste
  • Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP


Show Segments

  • Intro, disclaimer
  • GLP-1 + GIPs vs GLP-1s for patients with T2DM and Obesity – SURPASS-CVOT 
  • Weight Regain after Weight loss 
  • VALAD – Valacyclovir in patients with early Alzheimer’s 
  • Nudges to increase Deprescribing 
  • Outro


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Transcript

Click on a timestamp to play from that location

0:00.0

Hey, before we get to the show, I wanted to remind you to check out our Patreon at patreon.com

0:05.5

slash curbsiders. If you haven't signed up yet, sign up now to get ad-free episodes,

0:10.3

twice-monthly bonus episodes, and a whole bunch of other cool stuff at patreon.com slash curbsiders.

0:18.2

You know, Paul, I once had a dream I was floating in an ocean of orange soda.

0:27.8

Tell me more.

0:29.1

I can get there.

0:30.0

I know I can, but we only have so much time.

0:31.8

Actually, it was a fantasy.

0:33.7

It was a fantasy.

0:34.7

Yes, Paul.

0:35.6

Yes.

1:10.9

All right. Now I'm ready for the show. You're so good at guessing these. The Curbsiders podcast is for entertainment, education, and information purposes only, and the topics discuss should not be used solely to diagnose, treat, cure, or prevent any diseases or conditions. For the more of the views and statements expressed on this podcast are solely the host and should not be interpreted to reflect official policy or position of any entity aside from possibly cash like more honest, and affiliate outreach programs. If indeed, there are any. In fact, there are not. Pretty much, we aren't responsible if you screw up. You should always do your own homework and let us know when we're work. Welcome back to the curbsiders. I'm Dr. Matthew Frank Wado here with my great friend and America's primary care physician, pun expert, Dr. Paul Nelson Williams.

1:19.5

Hey, Paul.

1:20.5

Hey, Matt, how are you?

1:21.9

Good.

1:22.7

You've guessed a couple lately.

1:24.4

That's really, I got to get more clever with these.

1:28.8

Or the internet has to get more clever when it serves me these puns, is what I should say. Paul, we are doing a

1:35.9

digest episode tonight where we're going to run down some recent articles, news stories that we

1:41.4

thought were important for the audience to know about. And we have some,

1:45.4

we have two people with us who are, I'll say, smarter than me, Paul. You can, you can judge if

1:49.5

they're smarter than you. But Paul, I'm happy to have them here. Before we introduce them,

...

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