Welcome to Everyday Wellness Podcast.

I'm your host, nurse practitioner, Cynthia Thurlow.

This podcast is designed to educate, empower, and inspire you to achieve your health and wellness goals.

My goal and intent is to provide you with the best content and conversations from leaders in the health and wellness industry each week and

impact over a million lives.

Today is the second in a series of conversations with Dr. Tom Dayspring, as many of you already

know, he is an esteemed expert on not only

internal medicine, but also clinical lipidology. And today we are continuing our conversation

speaking at length about LP. Little A and the influence of gender, race, and menopause,

how estrogen is a PCS canine inhibitor, the importance of brain

health as well as risk for dementia, statin side effects, and who is most susceptible to the

brain effects of statins, the physiology of cholesterol synthesis, the significance of the biomarker

desmastrol, and levels to aim for, especially if you are

making decisions about cholesterol medications. And we tied in one listener question. Dr. Dayspring

graciously will be coming back to film an entire episode or episodes on diving into listeners' questions.

Again, you'll probably want to listen to this conversation more than once.

Now, before we tie up APOB, let's talk about goals.

So from your perspective, based on the data, based on your clinical experience, if someone does not have heart disease, does not have diabetes or any other, you know, diabetes adjacent diagnoses, where do you like to see their APOB?

Yeah. It's pretty easy. You know, for years, we've had the LVL cholesterol goals in a little and a little bit lately, something we didn't talk about, non-HD-L cholesterol, which is really your APLB cholesterol. Total cholesterol minus your HDL cholesterol is your APLB cholesterol. It's actually a little bit... Poor man's. Yeah, I'm of the poor man's APLB. It's a better guesstment of APLB then is LDL cholesterol. The NLA last year put out an exquisite treatise on this or so, letting you know that. But if you read the fine print, they will tell you APOB is even better than non-HDL cholesterol, but non-HL cholesterol is free. It would be, if you had to pay cash for it, it's a $20 test, so it's not that it's going to bankrupt too many people.

But, you know, many doctors don't know what APOB is, so patients have to get into an argument with their docs on what testing they want, and that's never fun.

The goals for LDL cholesterol pretty much came down to, in a primary prevention setting, if you could reduce the LDL cholesterol

to what is called the 20th percentile population cut point, that would mean if your LDLC is,

...