#429: Kevin Hall, PhD & Stephan Guyenet, PhD - Carbohydrate-Insulin Model vs. Energy Balance Model

Sigma Nutrition Radio

Danny Lennon

Sigma, Dietetics, Evidencebased, Nutrition, Training, Health & Fitness, Science, Diet, Fitness, Evidence, Bodybuilding, Health

4.8 • 626 Ratings

🗓️ 8 March 2022

⏱️ 107 minutes

🔗️ Recording | iTunes | RSS

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Summary

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The pathogenesis of obesity is clearly complex. And the need to have a comprehensive model to explain this pathogenesis is important.

One such model, termed the Energy Balance Model, has largely been the consensus paradigm of obesity scientists to this point. Specifically, a recently published paper in the American Journal of Clinical Nutrition by Dr. Kevin Hall and his colleagues outlined the various nuances of the model, as well as common misconceptions about the model.

However, there are others who propose that this is not the correct model of obesity, but rather that obesity pathogenesis can be better explained by a model called the Carbohydrate-Insulin Model (CIM) of obesity.

While this model has been proposed in various forms over the past couple of decades, the most recently published revision/update of this model was that put forward by Dr. David Ludwig and colleagues, in a Perspective published also in the AJCN, in December of 2021.

In this episode, Dr. Kevin Hall (lead author of the paper mentioned above) and Dr. Stephan Guyenet are on the podcast to discuss the debate surrounding these two models. Specifically, the discussion will focus in on the Hall et al. (2022) and Ludwig et al. (2021) papers, as well as previous work leading up to both.

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0:00.0	Welcome to another episode of Sigma Nutrition Radio. I am Danny Lennon. And if you're hearing this
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1:10.5	And without further ado, let's get into our episode.
1:35.9	This is Sigma Nutrition Radio. I'm your host, Danny Lennon, and today we are going to be talking about models of obesity.
1:45.5	So the pathogenesis obesity is clearly complex, and so the need to have a comprehensive model to explain this pathogenesis is something that's clearly important. We're going to be looking at a couple of models that have been put
1:50.5	forth to explain obesity pathogenesis in today's episode. The first model we'll be looking at is
1:57.6	something that has been referred to as the energy balance model, which we can think
2:01.7	of us largely being the consensus paradigm of obesity science to this point. And specifically,
2:09.0	we're going to be looking at this through the lens of a recently published paper in the American
2:13.0	Journal of Clinical Nutrition by Dr. Kevin Hall and his colleagues, and in that they discuss some nuances
2:19.5	of the model, as well as some aspects of another model that has been put forward recently.
	...

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