4.09 Problems with the VISION Trial & Stool Transplant Plus Nivo for Metastatic Melanoma

Plenary Session

Vinay Prasad, MD MPH

Health, Medicine, Policy, Oncology, Science & Medicine

4.7 • 789 Ratings

🗓️ 23 July 2021

⏱️ 27 minutes

🔗️ Recording | iTunes | RSS

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Summary

Today we have two short monologues for you on recent papers. The first, by popular request, is the problems with the VISION trial, which treated metastatic castration-resistant prostate cancer with lutetium-177–PSMA-617 (Lu-177–PSMA-617) radioligand therapy and standard of care. The second is on the paper recently published in Science titled "Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients". Fecal transplant: doi.org/10.1126/science.abb5920 Back us on Patreon! www.patreon.com/plenarysession Check out our YouTube channel: www.youtube.com/channel/UCUibd0E2kdF9N9e-EmIbUew

Transcript

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0:00.0	Welcome to Plenary Session.
0:07.9	I'm Vinay Prasad. I'm an associate professor with University of California, San Francisco.
0:11.9	I'm a practicing he-mong doctor, and my interests are medicine, oncology, and health policy.
0:16.4	And that's what you're going to get on Plenary Session.
0:21.6	This is season four, hashtag zero COVID.
0:24.6	It's zero COVID because we're not going to talk about COVID.
0:26.6	We're back, oncology, medicine, health policy.
0:29.6	We've got a lot in store for you.
0:33.6	But first, a plug.
0:34.6	If you like this podcast, leave us a rating or write us a review. It helps new listeners find the show. You can follow us on Twitter at Plenary underscore Session. You can email us at plenary session podcast at gmail.com. Give us your suggestions on what we should be covering. And we got a new YouTube channel, Vinay Prasad, MDMPH. Follow us on YouTube. I'm putting up a 10-part series on reading and interpreting cancer clinical trials.
0:57.6	You'll want to watch it there.
1:00.3	And if you really love this show, you can back us on patreon.com.
1:03.8	Patreon backers get access to slides for lectures I give on plenary session.
1:08.3	And with that, let's start the show. Dr. Vinay Prasad here from the University of California,
1:13.7	San Francisco. By request, I'm going to talk about that science paper everyone's been buzzing about.
1:18.7	This is where they took metastatic melanoma patients who had progressed on PD1 or PDL1 therapy.
1:23.5	They reintroduced nivolomab, but topped it off with a fecal transplant, and they got 30% response rate, and everyone was celebrating.
1:31.1	This is the power of the microbiome, and we're finally harnessing it.
1:35.7	Well, are we?
1:36.7	I took a look at this paper and let me show you what I found about it.
1:40.5	Here it is, of course, science, the crem de la crem of the biomedical literature, but don't think
1:45.2	about that because this is fecal microbiota transplant, promoting response and immunotherapy
	...

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