#338 ‒ Peter’s takeaways on aerobic exercise and VO2 max, insulin resistance, rising healthcare costs, treating children with autism and ADHD, and strength training | Quarterly Podcast Summary #4

The Peter Attia Drive

Peter Attia, MD

Health & Fitness, Medicine, Fitness

4.7 • 7.3K Ratings

🗓️ 3 March 2025

⏱️ 28 minutes

🔗️ Recording | iTunes | RSS

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Summary

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In this quarterly podcast summary (QPS) episode, Peter summarizes his biggest takeaways from the last three months of guest interviews on the podcast. Peter shares key insights from his discussions on diverse topics such as aerobic efficiency and VO2 max with Olav Aleksander Bu; insulin resistance with Ralph DeFronzo; economics of the US healthcare system and cost-saving strategies with Saum Sutaria; diagnosis and treatment of autism, ADHD, and anxiety in children with Trenna Sutcliffe; and strength training with Mike Israetel. Additionally, Peter shares any personal behavioral adjustments or modifications to his patient care practices that have arisen from these fascinating discussions.

If you’re not a subscriber and are listening on a podcast player, you’ll only be able to hear a preview of the AMA. If you’re a subscriber, you can now listen to this full episode on your private RSS feed or our website at the episode #338 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here.

We discuss:

Overview of topics to be discussed [2:00];
Olav Aleksander Bu Pt.2 episode: metrics to track aerobic efficiency and insights about VO2 max, and the ability of increased carbohydrate consumption to boost performance [4:30];
The best practices for performing a VO2 max test, the differences between VO2 max training and all-out efforts, and the role of energy intake in endurance performance [14:45];
Ralph DeFronzo episode: the pathophysiology of insulin resistance and type 2 diabetes—how they impact different organs, flaws in conventional diabetes treatment, and more [24:30];
Understanding type 2 diabetes beyond the traditional triumvirate of features: the “ominous octet” describes changes in other organs [31:45];
Pharmacological treatments for insulin resistance and type 2 diabetes [41:30];
The importance of early detection and intervention in insulin resistance [50:30];
Saum Sutaria episode: the economic and systemic drivers of high healthcare costs in the U.S. [54:00];
Reducing health care costs: redefining health insurance, lowering drug prices while maintaining innovation, leveraging AI for efficiency, and more [1:07:15];
Trenna Sutcliffe episode: insights on autism, ADHD, and anxiety in children—definitions and diagnosis [1:11:45];
Exploring the rising prevalence of autism spectrum disorder [1:17:15];
Trenna’s views on caring for children with autism [1:21:15];
Misconceptions around vaccines and autism [1:26:00];
Mike Israetel episode: insights about strength training, minimum effective dose, troubleshooting plateaus, tips for beginners, and more [1:28:15];
Topics Peter is interested in exploring in future podcasts [1:40:15]; and
More.

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Transcript

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0:00.0	Hey everyone. Welcome to a sneak peek, Ask Me Anything, or AMA episode of the Drive podcast. I'm your host, Peter Attia. At the end of this short episode, I'll explain how you can access the
0:21.0	AMA episodes in full, along with a ton of other membership benefits we've created. Or you can learn
0:26.4	more now by going to Peter Atiyahmd.com forward slash subscribe. So without further delay,
0:32.8	here's today's sneak peek of the Ask Me Anything episode.
0:42.7	Welcome to another special AMA episode of The Drive.
0:46.7	Today's episode will be the fourth installment of the quarterly podcast summary.
0:54.3	In this conversation, I discuss what I learned from the last quarter of interviews and what I think were some of the most important insights, as well as things that have resulted in a change in my work and behavior. Please note that I do not think
1:00.3	listening to the quarterly podcast summary even remotely constitutes a substitute for listening to
1:06.3	the actual episodes. My hope is that it basically helps you think about refining what you might have learned
1:12.3	there. And if something you hear in one of these summaries is of interest and you miss the
1:17.3	original episode, I hope you'll go back and listen to it. In today's episode, we cover the
1:21.6	interviews that I did with Olaf, Alexander Boo, Ralph DeFranzo, Sam Soutaria, Trenna Sutcliffe, and Mike Ishtratel.
1:30.9	And throughout these, we talk on various topics.
1:34.0	V-O-2 Max.
1:35.0	Power at V-O-2 Max, insulin resistance, metformin, SGLT-2 inhibitors, GLP1 agonists, U.S.
1:40.6	healthcare costs, diagnosis and treatment approaches to autism, ADHD and anxiety,
1:46.6	zone to resistance training, and learning all of the effects of anabolic steroids. And yeah,
1:54.0	that sounds like a hodgepodge of topics, but that's because it's pulled from all of these
1:58.3	discussions. If you're a subscriber, anyone watch the full video
2:01.4	of this podcast, you can find it on our show notes page. If you're not a subscriber, you can watch
2:06.5	the sneak peek of the video on our YouTube page. So without further delay, I hope you enjoy this
2:11.1	special quarterly podcast summary AMA of the Drive.
	...

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