Hello, my name is Danny Lennon, and this is Sigma Nutrition Radio, the podcast that brings you

conversations about nutritional and health science. And today we're going to be tackling a topic

that is not only extremely interesting from the nerdy, nuanced details of human metabolism,

but also has very real and important practical implications

for the population at large, as well as those of you who may be working as practitioners,

helping people with their health and nutrition.

And it mainly centers around the idea that we know when weight loss occurs and whether that's through

a dietary intervention or a combination with physical activity, essentially when an energy

reduced state is induced to lead to weight loss over time. If someone, let's say, is trying

to improve their health through that change in adiposity, that once that weight loss is achieved, the maintenance

of that weight loss in the long term can be extremely difficult. And when you look at the numbers,

most often you do tend to see regain of body weight in a large number of those for several

different reasons. And of course we have this

increased drive to eat after a loss of a certain amount of body weight and a certain degree of

caloric restriction. And we have various metabolic adaptations that happen as well. And these have been

discussed on this podcast in previous episodes before.

So if we know that this long-term maintenance of weight loss that we're trying to achieve

requires a sustained energy balance at this new reduced body weight, there's a couple of different

ways that that could actually be achieved. One could, you could have a low energy intake matched up with

a relatively low physical activity. Or at the other end of the spectrum, you could have a very high

energy intake but matched up with a very high energy expenditure. And in both of those situations,

we're still at energy balance. Now, those states could be characterized respectively as a low

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