4.8 • 4.4K Ratings
🗓️ 9 June 2025
⏱️ 75 minutes
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The human brain is extremely complicated, but decades of careful neuroscientific research have revealed quite a bit about how it works, including how certain genes affect particular brain behaviors. Nevertheless, this progress has not led to quite as much improvement in the treatment of brain disorders as we might expect. I talk with neuroscientist Nicole Rust about why this is and how to improve the situation, as discussed in her new book Elusive Cures.
Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/06/09/317-nicole-rust-on-why-neuroscience-hasnt-solved-brain-disorders/
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Nicole C. Rust received her Ph.D. in neuroscience from New York University. She is currently a professor of psychology at the University of Pennsylvania. She is also a contributing editor at The Transmitter and an editor at BrainFacts.org. Among her awards are the Troland Research Award from the National Academy of Sciences.
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0:00.0 | Hello, everyone, and welcome to the Mindscape Podcast. I'm your host, Sean Carroll. Back when I was |
0:05.5 | writing The Big Picture, the book, one of the motivations there was to provide kind of an |
0:10.8 | apologia for naturalism, an epilogia not being, you say you're sorry, you apologize, |
0:17.6 | it's when you defend a position, okay, mostly coming from theology. Apologetics in |
0:24.4 | theology is you're trying to defend the existence of God. So I was doing the opposite, or at least |
0:28.8 | the flip side, defending the absence of God, defending the idea that even though we don't know |
0:35.2 | everything about how the universe works, given what we do know, |
0:39.5 | there's overwhelming reason to believe that when we finally know everything, it will all fit |
0:44.7 | in happily to a naturalistic framework where you don't need supernatural things, you |
0:49.2 | don't need God, anything like that. |
0:50.7 | You don't need a spark of life to make life go. |
0:53.7 | You don't need an immaterial soul to make life go. You don't need an immaterial |
0:55.0 | soul to make consciousness go and so forth. And it's always going to be a tricky thing to make |
1:01.0 | a case like that because you're admitting that you don't know the final answers. So you can't say, |
1:06.0 | here is the final answer. You're making a claim that it is probable, or you should have the most credence, |
1:12.5 | that when the future final answer comes, will take a certain form. And to do that, you have to |
1:17.9 | face up to some of the issues. And of course, the bridge from the brain to the mind is one of the |
1:26.4 | biggest issues that you have to face up to. You can see why |
1:30.8 | there's plenty of people, philosophers, and other people who will want to accept the idea |
1:37.4 | that the mere physical motion of stuff that makes up the brain is not enough to account for |
1:44.0 | consciousness or feelings or whatever it is |
1:46.9 | that you have your attention focused on when you're thinking about the brain. |
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