303. Testosterone and Mood -A New Paper

You Are Not Broken

Kelly Casperson, MD

Medicine, Health & Fitness

5 • 743 Ratings

🗓️ 9 February 2025

⏱️ 45 minutes

🔗️ Recording | iTunes | RSS

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Summary

In this conversation, Dr. Kelly Casperson discusses a significant study on the effects of transdermal testosterone therapy on mood and cognitive symptoms in peri- and postmenopausal women. She emphasizes the importance of addressing hormonal changes and their impact on women's mental health, particularly during menopause. The study reveals that testosterone therapy can lead to improvements in mood and cognitive function, challenging the notion that there is insufficient data on testosterone's benefits for women. Dr. Casperson also critiques the study's limitations and calls for further research in this area, while engaging with her audience on related questions and concerns. Takeaways Testosterone therapy can improve mood and cognitive symptoms in women. The study involved 510 women with persistent low libido and mood symptoms. Mood improvements were more significant than cognitive improvements. Testosterone does not drop off a cliff with menopause; it declines gradually. Hormonal changes during menopause can lead to increased risk of depression and cognitive impairment. Testosterone therapy may be a safer alternative to SSRIs for mood issues in perimenopausal women. The study highlights the need for more research on testosterone's effects in women. Libido is closely linked to mood; improving one can enhance the other. Transdermal testosterone is generally safe and easy to administer. Women should be informed about their options for hormone therapy. Study LINK Glynne S, Kamal A, Kamel AM, Reisel D, Newson L. Effect of transdermal testosterone therapy on mood and cognitive symptoms in peri- and postmenopausal women: a pilot study. Arch Womens Ment Health. 2024 Sep 16. doi: 10.1007/s00737-024-01513-6. Epub ahead of print. PMID: 39283522. Sedona in October: https://www.ascendretreats.com/menopause-and-sexual-health-2025 Order my book "You Are Not Broken: Stop "Should-ing" All Over You Sex Life" Listen to my Tedx Talk: Why we need adult sex ed Take my Adult Sex Ed Master Class: My Website Interested in my sexual health and hormone clinic? Starts 2025. Thanks to our sponsor Midi Women's Health. Designed by midlife experts, delivered by experienced clinicians, covered by insurance. Midi is the first virtual care clinic made exclusively for women 40+. Evidence-based treatments. Personalized midlife care. https://www.joinmidi.com Thanks to our sponsor Sprout Pharmaceuticals. To find out if Addyi is right for you, go to addyi.com/notbroken and use code NOTBROKEN for a $10 telemedicine appointment. See Full Prescribing Information and Medication Guide, including Boxed Warning for severe low blood pressure and fainting in certain settings at addyi.com/pi To learn more about Via vaginal moisturizer from Solv Wellness, visit via4her.com for 30% off your first purchase of any product, automatically applied at checkout. For an additional $5 off, use coupon code DRKELLY5. Learn more about your ad choices. Visit megaphone.fm/adchoices

Transcript

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0:00.0	Did you know that I can prescribe an FDA-approved pill to boost your sex drive, ladies?
0:05.5	Yes, there's an FDA-approved treatment called Addie that is clinically proven to boost libido
0:11.2	in certain premenopausal women bothered by low sex drive. Some call Addie the little pink pill.
0:18.1	You know how passionate I am about your sexual wellness. And I've witnessed
0:22.1	firsthand what treating a woman with Addie can do for her. Speak to your doctor about Addy if you're
0:28.1	struggling. Even talk to a telehealth doctor online today at ADDY.com. You deserve to get your sex drive back.
0:38.6	Addie, or Flavansarin, is for premenopausal women with acquired generalized hypoactive
0:42.2	sexual desire disorder, HSDD, who have not had problems with low sexual desire in the past,
0:46.5	who have low sexual desire no matter the type of sexual activity, the situation, or the sexual
0:50.5	partner. The low sexual desire is troubling to them and is not due to a medical or mental health
0:54.6	problem, problems in the relationship, or medicine or other drug use.
0:57.6	Adi is not for use in men or to enhance sexual performance.
1:00.4	Your risk of severe low blood pressure and fainting is increased if you drink one to two
1:03.7	standard alcoholic drinks close in time to your Adi dose.
1:06.2	Wait at least two hours after drinking before taking Adi at bedtime. Your risk of severe low blood pressure and fainting is also increased if you take certain
1:12.5	prescriptions, over-the-counter or herbal medications, or have liver problems.
1:16.0	Low blood pressure and fainting can happen when you take Adi, even if you don't drink
1:19.2	alcohol or take other medicines.
1:20.6	Do not take if you are allergic to any of the ingredients in Adi.
1:23.3	Allergic reactions may include hives, itching, or trouble breathing. Sleepiness, sometimes serious, can occur.
1:28.1	Common side effects include dizziness, nausea, tiredness, difficulty falling asleep or staying asleep and dry mouth.
1:32.9	See full PI and medication guide, including boxed warning at adi.com slash PI or call 844 pink pill.
	...

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