#300 - Special episode: Peter on exercise, fasting, nutrition, stem cells, geroprotective drugs, and more — promising interventions or just noise?

The Peter Attia Drive

Peter Attia, MD

Health & Fitness, Medicine, Fitness

4.7 • 7.3K Ratings

🗓️ 6 May 2024

⏱️ 100 minutes

🔗️ Recording | iTunes | RSS

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Summary

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In this special edition celebrating 300 episodes of The Drive, Peter discusses a variety of popular topics and health interventions and classifies them based on their level of evidence and relevance using the following categories: proven, promising, fuzzy, noise, and nonsense. Peter first delves into the topic of geroprotective molecules, covering rapamycin, metformin, NAD and its precursors, and resveratrol. Next, he explores the significance of metrics like VO2 max and muscle mass, as well as emerging concepts like blood flow restriction and stem cells. The conversation extends to nutrition, addressing questions surrounding long-term fasting, sugar consumption, sugar substitutes, and the contentious role of red meat in cancer. Peter not only provides his current stance on each topic—most of which have been covered in great detail in the previous 300 episodes—but also reflects on how his opinion may have evolved over the years.

We discuss:

Defining the categories of “proven, promising, fuzzy, noise, and nonsense” [3:15];
Rapamycin [9:30];
Metformin [17:00];
NAD and its precursors [24:30];
Resveratrol [32:45];
The importance of VO2 max, muscle mass, and muscular strength for lifespan [38:15];
Blood flow restriction (BFR) training [44:00];
Using stem cells to treat osteoarthritis or injury [51:30];
Fasting as a tool for longevity (and why Peter stopped his fasting protocol) [55:45];
The energy balance theory [1:06:30];
The idea that sugar is poison [1:12:00];
The idea that sugar substitutes are dangerous [1:22:15];
The debate on red meat and cancer [1:28:45]; and
More.

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Transcript

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0:00.0	Hey everyone. Welcome to the Drive Podcast. I'm your host, Peter Attia. This
0:15.7	podcast, my website, and my weekly newsletter all focus on the goal of
0:19.6	translating the science of longevity into something accessible for everyone.
0:24.0	Our goal is to provide the best content in health and wellness,
0:27.0	and we've established a great team of analysts to make this happen.
0:31.0	It is extremely important to me to provide all of this content without relying
0:34.9	on paid ads. To do this, our work is made entirely possible by our members, and in return,
0:40.3	we offer exclusive member-only content and benefits above and beyond what is available for free.
0:46.0	If you want to take your knowledge of this space to the next level, it's our goal to ensure members get back much more than the price of the subscription.
0:54.0	If you want to learn more about the benefits of our premium membership,
0:58.0	head over to Peter AttiaMD.com
1:01.0	forward slash subscribe.
1:07.0	Welcome to a special episode of the drive. Today we celebrate our 300th episode.
1:10.0	To celebrate this milestone we're going to do something a little different for this episode, but it's going to mirror the structure of a recent interview I did which I thought was kind of interesting.
1:19.0	For today's episode, we're going to cover a variety of topics, which you have all weighed in on and I'm going to rank them
1:26.0	into the following categories proven promising fuzzy noise and nonsense.
1:31.6	A couple of months ago some of you may recall I put out a video on
1:34.3	social media where I asked people to weigh in on the types of topics that they
1:39.6	wanted to hear covered and we got a lot of responses, literally thousands of responses.
1:45.5	We've sorted those into different categories and we're about to cover half of them here.
1:50.7	Turns out the response was far in excess of what we predicted and we'll have to finish this another time.
1:56.0	But nevertheless in this conversation, we're going to cover guroprotective drugs, including rapomycin, NAD, and its precursors, Metformin, Resveratrol. of And then we talk about nutrition, specifically questions you had around long-term fasting, sugar,
	...

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