Hello, you are listening to Sigma Nutrition Radio, the podcast that brings you conversations

about nutritional and health science.

I am your host, Danny Lennon, and if you're like me, then anytime you think about the

relationship between calories in and calories out, you will of course know that it's not this kind of linear input

output idea, but also that throws up some interesting questions. So for example, when we change

energy intake, how does that exactly change our energy expenditure? One of the things we know, of course,

is in dieting conditions, we see metabolic adaptations

to that reduced energy intake. So now we're starting to see this interplay between energy intake

and expenditure. But beyond that, there are other interesting things we see in research that lead

us to more questions. So for example, we see this compensation to an energy imbalance appears to be

asymmetrical, that when we overeat or under eat, those adaptive responses are different. We also

see very different inter-individual responses. And also then it throws up this question of,

if we are going to put someone in a caloric deficit, does it matter

if that's done through caloric restriction, added exercise, or some combination of both? If the

deficit on paper looks the same, does that actually mean the same in practice? Or do we see a different

interplay by how we actually induce some of that deficit?

Well, to answer some of these questions, today I'm delighted that I'm going to be able to be talking to Dr. Mark Hopkins from the University of Leeds.

Dr. Hopkins is a lecturer in nutritional physiology, and he's been carrying out research for many years at this point,

which is focused primarily on the physiological mechanisms of appetite control,

and that interaction between diet, physical activity, and appetite control.

So this includes examining the physiological and behavioral responses to dietary

and exercised induced weight loss. And so he is in a perfect position to hopefully answer

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