4.7 • 7.3K Ratings
🗓️ 30 January 2023
⏱️ 114 minutes
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Dan Rader is a Professor at the Perelman School of Medicine at the University of Pennsylvania, where he conducts translational research on lipoprotein metabolism and atherosclerosis with a particular focus on the function of high-density lipoproteins (HDLs). In this episode, Dan goes in-depth on HDL biology, including the genesis of HDL, its metabolism, function, and how this relates to atherosclerotic cardiovascular disease (ASCVD). He explains why having high HDL-C levels does not directly translate to a low risk of cardiovascular disease and reveals research pointing to a better way to measure the functionality of HDL and predict disease risk. He also goes into detail on the role of HDL in reverse cholesterol transport and the benefits this has for reducing ASCVD. Additionally, Dan discusses the latest thinking around the association between HDL cholesterol and neurodegenerative diseases and ends the conversation with a discussion of how the latest research on HDL provides a promising outlook for ongoing trials and future therapeutic interventions.
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0:00.0 | Hey everyone, welcome to the Drive Podcast. |
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0:46.3 | Now, without further delay, here's today's episode. |
0:49.0 | I guess this week is Dan Radar. |
0:53.0 | Dan is a professor of molecular medicine at the Perlman School of Medicine at the University |
0:58.0 | of Pennsylvania, where he conducts translational research on lipoprotein metabolism and |
1:02.8 | atherosclerosis, with a particular focus on the metabolism and, most importantly, function |
1:08.6 | of high-density lipoproteins, HDLs. |
1:12.4 | Dan has received numerous awards and has been elected to the American Society of Clinical |
1:16.4 | Investigation, the Association of American Physicians, and the National Academy of Medicine. |
1:20.5 | He also currently serves on the Board of Directors of the International Society of |
1:24.2 | Atherosclerosis, the Board of External Experts at the National Heart Lung and Blood Institute, |
1:29.8 | and the Advisory Board for the Clinical Research of the NIH. |
1:32.9 | In this episode, we focus our entire conversation around high-density lipoproteins or HDLs. |
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