2025 Biohacking State of the Union: Master Supplementation Guide with Dr. Sandra Kaufmann : 1243
The Human Upgrade with Dave Asprey
Dave Asprey
4.6 • 7.3K Ratings
🗓️ 21 January 2025
⏱️ 93 minutes
🧾️ Download transcript
Summary
What if you could cheat aging, indulge in life’s guilty pleasures, and still thrive?
Dr. Sandra Kaufmann, a pioneering longevity expert and fearless explorer of the biochemical frontier, joins Dave to reveal how you can bend the rules of biology to live longer, smarter, and stronger. Forget perfection—Dr. Kaufmann’s radically practical approach embraces the human side of longevity, showing you how to optimize your body while enjoying the ride.
From downing Diet Cokes to defying traditional medical dogma, she’s rewritten the playbook on anti-aging with her Seven Tenets of Aging. Together, she and Dave dive into everything from molecular hacks for outsmarting junk food to unlocking the secret power of your mitochondria, DNA, and circadian rhythms. This episode goes beyond the surface with mind-blowing insights, hilarious moments, and actionable steps to take your health (and your fun) to the next level.
What You’ll Learn:
• The Seven Tenets of Aging and how they’ll change your approach to health
• Why indulging in “bad” habits doesn’t have to sabotage your longevity
• Biochemical secrets to combat oxidative stress, glycation, and cellular junk
• The real story behind NAD, circadian rhythms, and the tools for better sleep
• How to create a personalized health plan that’s sustainable, effective—and fun
Resources:
• Supplement Protocol One-Sheet for this episode: https://www.instagram.com/dave.asprey/?hl=en
• 2025 Biohacking Conference: https://biohackingconference.com/2025
• Kaufmann Protocol Website: https://kaufmannprotocol.com
• Sandra Kaufmann’s Book – Why We Age and How to Stop It: https://www.amazon.com/Kaufmann-Protocol-Why-Age-Stop/dp/0692089047
• Sandra Kaufmann’s Instagram: https://www.instagram.com/kaufmannantiaging/?hl=en
• Danger Coffee: https://dangercoffee.com
• Dave Asprey’s Website: https://daveasprey.com
• Dave Asprey’s Book – Smarter Not Harder: https://daveasprey.com/books
• Dave Asprey’s Linktree: https://linktr.ee/daveasprey
• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
• Own an Upgrade Labs: https://ownanupgradelabs.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
SPONSORS:
Leela Quantum | Head to https://leelaq.com/DAVE for 10% off.
Timeline | Head to https://www.timeline.com/dave to get 10% off your first order.
Timestamps:
• 00:00 Trailer
• 00:45 Guest Introduction
• 02:30 Longevity Insights
• 04:22 Personal Stories
• 08:00 Pharmaceuticals
• 12:26 Diet and Lifestyle
• 18:19 Seven Tenets
• 22:04 Sleep and Circadian Rhythms
• 26:41 NAD and Supplements
• 37:46 Blood Sugar and AGEs
• 47:09 Microcirculation
• 49:08 NRS and Imports
• 49:18 Celebrex Medication
• 50:03 Celebrex Benefits
• 50:41 Alzheimer’s and Celebrex
• 51:28 Antioxidants
• 54:26 Stem Cells and Exosomes
• 58:03 Laser Skin Treatments
• 01:07:34 Hormones and Longevity
• 01:20:03 Lithium for Mood
• 01:27:45 Gender and Longevity
• 01:32:39 Final Thoughts
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Transcript
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| 0:00.0 | Dr. Sandra Kaufman, one of the smartest longevity docs. Why on earth would you drink Diet Coke? |
| 0:05.4 | Because it's delicious and it's refreshing. I feel so dirty. I'm sitting in a room with someone who doesn't |
| 0:10.2 | drink coffee. No, I don't. Would you take stem cells? I don't like the idea of someone else's DNA |
| 0:15.7 | being in my body. I take birth control. Take birth control? Have you not seen the studies about |
| 0:20.0 | what that does for your risk of cancer and all these other things? |
| 0:23.2 | But you have to understand why it causes cancer. |
| 0:25.5 | Oh, my God. |
| 0:26.3 | You're like the worst longevity doctor ever. |
| 0:28.2 | What is the number one medication that can be used for longevity that no one's ever heard of? |
| 0:35.0 | You're listening to The Human Upgrade with Dave Asprey. |
| 0:40.9 | This episode is recorded live in the studios here in Austin, and a good friend has flown in |
| 0:48.6 | specifically for this episode. |
| 0:51.4 | We're both heading to the American Academy of Anti-Aging Medicine tomorrow. |
| 0:56.3 | This is a very weird longevity doctor. |
| 0:59.8 | I'm just going to have to say that. |
| 1:01.3 | And that is one of the highest compliments that I could pay someone. |
| 1:05.1 | Dr. Sandra Kaufman, or Sandy, as she's known by her friends and colleagues, |
| 1:09.2 | is a former chief of pediatric anesthesia |
| 1:12.2 | and a longevity expert and an author. And one of the smartest longevity docs I've ever had |
| 1:18.6 | the pleasure of becoming friends with. We've hung out multiple times and this crazy person, |
| 1:25.8 | I'm just going to have to say this, will order the Diet Coke, the |
| 1:30.5 | Freetoes, the cupcakes, and all of the crap that would knock me on my face if I ate it. And she's |
... |
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