2.11 Questions of the Week, When RCTs are Necessary, & AYA Oncology with Dr. Adam Duvall

Plenary Session

Vinay Prasad, MD MPH

Policy, Oncology, Science & Medicine, Medicine, Health

4.8 • 798 Ratings

🗓️ 12 September 2019

⏱️ 101 minutes

🔗️ Recording | iTunes | RSS

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Summary

After a hiatus from our segment on reviewing recent trials, we return to discuss the need for randomized controlled trials (RCTs). In the wake of the 2019 World Conference on Lung Cancer, we focus on whether a phase III trial of selpercatinib (LOXO-292) in RET rearranged lung cancer is feasible, practical, and ethical. We also have two questions of the week in this episode -- one from Dr. Derrick Tao, inspired by the MKSAP; and one from Dr. Sven Olson on hematology and oncology -- as well as an interview with Dr. Adam Duvall of OHSU on his career in the field of adolescent and young adult (AYA) oncology. Back us on Patreon! patreon.com/plenarysession

Transcript

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0:00.0	Welcome to Plenary Session.
0:07.0	I'm your host, Dr. Vinay Prasad.
0:09.0	I'm a practicing hematologist oncologist and I'm associate professor of medicine.
0:14.0	I'm interested in issues at the intersection of medicine, oncology, and health policy,
0:19.0	and that's what you're going to get on this podcast.
0:22.2	Welcome to Season 2.
0:25.6	This week on Plenary Session, we have an interview with Dr. Adam Duvall, who's an expert on
0:30.6	A.Y.A, adolescent and young adult oncology, and he's here to tell you why that career is so rich,
0:36.4	interesting, and satisfying.
0:38.6	We also have a couple questions to you coming this week, because this is Plenary Sessions,
0:41.7	season two, and that's what you're going to get on this podcast.
0:45.0	But first, I want to take a minute and talk about randomized control trials.
0:49.7	Recently, we had the World Conference on Lung Cancer and the tweets came out fast and furious,
0:54.8	and people are saying a Phase 3 randomized controlled trial for RET-rearranged lung
0:59.4	cancer is neither feasible nor practical nor ethical.
1:03.3	So we're going to take a close look at that claim and learn the truth about when randomized
1:07.0	trials are necessary and when they are not.
1:09.1	It's quite simple.
1:10.3	And let's see how these tweets fare.
1:12.8	But first, a thanks.
1:14.7	I want to thank those of you who've gone online and support this podcast on patreon.com.
1:19.5	Patreon subscribers get access to the slides from lectures I give on plenary session.
	...

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