4.8 • 1K Ratings
🗓️ 22 September 2025
⏱️ 39 minutes
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Medications for orthostatic hypotension! When to initiate treatment, how to use them safely, and what to do when new issues arise during treatment. How do those change if someone has autonomic failure? What do you do when your patient has hypertension AND also has orthostatic hypotension?
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Timestamps (+/- 1-2 mins):
(00:28) | Case Recap: Beyond Non-Pharm Strategies
(03:07) | Midodrine: Timing, Testing, & Supine Hypertension
(06:23) | Fludrocortisone: Benefits vs. Risks
(09:01) | Droxidopa: Evidence, Side Effects, Access Issues
(10:11) | Pyridostigmine & NSAIDs: Secondary Options
(12:31) | Balancing Hypertension and Orthostatic Hypotension
(14:29) | Functional Hypotension & Risk Stratification
(18:45) | Symptomatic Patients: What to Stop, What to Continue
(20:19) | Autonomic Disease: Supine & Nocturnal Hypertension
(21:47) | Bed Elevation, Compression, & Non-Pharm Pearls
Tags: Internal Medicine, Geriatrics, Autonomic Dysfunction, Hypertension, Syncope, Falls, Patient Safety, Medical Education, physician assistant, nurse practitioner, hospitalist, primary care, neurology
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| 0:00.0 | This podcast is for educational and informational purposes only and does not constitute formal medical advice, clinical guidance, or institutional policy. |
| 0:07.9 | The views expressed are those of the hosts and guests and may not reflect those of any official policies or affiliated organizations. |
| 0:14.1 | Always verify information, console appropriate resources, and apply your own clinical judgment before caring for patients. |
| 0:20.7 | Welcome to Gray Matters, where we unpack how medical management is rarely black or white. |
| 0:25.0 | And go on deep dyes along the way. |
| 0:27.1 | I'm Dr. Nick Falano. |
| 0:28.5 | I'm Dr. Shera Chavetti. |
| 0:29.9 | And on our last episode on Orthostatic Hypotension, Nick brought a really interesting case to the |
| 0:34.8 | Gray Matters table. |
| 0:35.5 | It was a 72-year-old male whose hospital |
| 0:37.6 | course was complicated by orthostatic hypotension, and we figured out it wasn't dehydration |
| 0:42.9 | or some other easily reversible cause. We reviewed some meds. We stopped some isisorbid mononitrate. |
| 0:49.0 | Yep. I also gave him an abdominal binder. I told him to eat more, smaller meals throughout the day |
| 0:54.0 | instead of just a few big |
| 0:55.1 | ones. And I even taught him this cool drink water really quickly trick that we talked about last |
| 1:00.4 | episode, if you missed that. And physical therapy taught him some in-bed exercises to keep up his |
| 1:05.6 | strength. Yes, Nick, I really want to believe that chugging cold water really fast in the morning |
| 1:10.2 | did the trick and he's all cured and ready for discharge. |
| 1:13.4 | Same here. I would have felt so cool if that worked. It did help, but unfortunately didn't fix all his problems. |
| 1:18.5 | His standing blood pressures did improve, but they were still in the high 80s, systolic when standing. |
| 1:24.2 | And his symptoms decreased, but they were still not totally tolerable for him. |
| 1:28.1 | And physical therapy thought that he could use a little extra help. |
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