#180 Beta-Blockers & REDUCE-AMI Trial: Beyond Journal Club Segment with NEJM Group

Core IM | Internal Medicine Podcast

Core IM Team

Mental Health, Education, Health & Fitness, Medicine

4.8 • 1K Ratings

🗓️ 25 June 2025

⏱️ 32 minutes

🔗️ Recording | iTunes | RSS

🧾️ Download transcript

Summary

How much do beta blockers help after a heart attack, even when the heart’s pumping well? In this episode, we revisit the origins of beta blockers in post-MI care, examine how evidence evolved, and explore the REDUCE-AMI trial, which questions whether beta blockers are still needed for all.

Listen to this latest episode of Beyond Journal Club, a collaboration between Core IM and NEJM Group, where we put research into context tracing the arc of evidence, dissecting the clinical question, and exploring what the findings could mean for real-world patient care

🔹 Sponsor: NEJM Fellowship Program, click here to learn more and/or apply!

🔹 Transcript and Show Notes

Timestamps:

(00:48) | Background on Beta Blockers and Their Mechanism

(02:41) | Historical Context of Beta Blockers in Heart Disease

(04:56) | Capricorn Trial and Its Impact

(07:17) | Emergence of Doubts About Beta Blockers

(10:09) | Introduction to the REDUCED-AMI Trial

(15:52) | Discussion on Trial Interpretation and Clinical Implications

(16:18) | Comparison with Other Trials and Future Directions

Tags: CoreIM, Internal Medicine, Primary Care, Medical Education, IMCore, Physician Assistant, Nurse Practitioner, Medical Student, Cardiology

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Transcript

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0:00.0	I am so excited to have N.E. Jam's editorial fellowship program as a sponsor for this podcast.
0:05.6	Here from Dr. Urbana Pearl and N.E.J.M. Editorial Fellow on her experiences.
0:10.5	The working environment is so friendly to the point where a dog attends our editorial meeting, a dog means scout.
0:19.6	And he frequently comes to smell my lunch lunch in my back hat and so on.
0:24.5	So, yeah, people like Eric Rubin, the editor-in-chiefs are very personable and approachable,
0:31.3	and I'm going to miss this year so much. I think anyone who's chosen for this, the role has a lot to look forward to. So if you're willing to
0:40.8	learn and try something new, if you have a little bit of a creative streak perhaps, and you're
0:47.0	interested in taking a step back and seeing medicine from a bird's eye perspective. I think that's all you really need.
0:55.5	And this is a one-year, full-time paid editorial fellowship. Check out the show notes for the link
1:01.1	and learn more about the program and the application. Welcome to another episode of Beyond Journal
1:06.1	Club, a collaboration between Core I.M and NEJM group. The goal of Beyond Journal Club is to take landmark clinical trials and put them into context,
1:13.8	telling the story of how we got to where we are and what it means for how we take care of our patients.
1:18.3	I'm Dr. Shreda Chravetti and internist at VIDMC.
1:21.1	I'm Dr. Greg Katz, cardiologist at NYU.
1:24.4	I'm Dr. Chris Cotonidis and a editorial fellow at the New England Journal of Medicine.
1:29.2	And I'm Dr. Clemley, a former fellow and a current guest editor of the New England Journal of
1:32.8	Medicine. Today, we'll be discussing the reduced AMI trial. This trial explored the role of
1:39.1	beta blockers in patients with a recent heart attack. This is one of those studies that makes me think
1:43.9	of that old adage they tell you when you start
1:45.6	med school. In 10 years, half of what you learn is going to be wrong. The problem is that we don't
1:50.6	know now which half it is. Yeah, it's so funny that we were all told that. And I'm so excited to
1:55.8	get into this, because for at least as long as I can remember, beta blockers have been considered the standard treatment after a heart attack.
	...

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