meta_pixel
Tapesearch Logo
Log in
Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas

16 | Coleen Murphy on Aging, Biology, and the Future

Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas

Sean Carroll

Physics, Science

4.74.7K Ratings

🗓️ 1 October 2018

⏱️ 64 minutes

🧾️ Download transcript

Summary

Aging -- everybody does it, very few people actually do something about it. Coleen Murphy is an exception. In her laboratory at Princeton, she and her team study aging in the famous C. Elegans roundworm, with an eye to extending its lifespan as well as figuring out exactly what processes take place when we age. In this episode we contemplate what scientists have learned about aging, and the prospects for ameliorating its effects -- or curing it altogether? -- even in human beings. Coleen Murphy received her Ph.D. in biochemistry from Stanford University, and is currently Professor in the Department of Molecular Biology and the Lewis-Sigler Institute of Integrative Genomics at Princeton. Home page at the Lewis-Sigler Institute Lab web page Princeton Profile Google Scholar publication page Twitter

Transcript

Click on a timestamp to play from that location

0:00.0

Hello everyone and welcome to the Mindscape Podcast.

0:03.6

I'm your host, Sean Carroll, and like most of you, I am getting older.

0:08.5

When I was your age, we didn't even have podcasts.

0:10.9

If we wanted to listen to this American life, we had to turn on the radio and listen to

0:16.1

it coming over the airwaves, and that's how we liked it.

0:19.7

As a physicist, I studied the arrow of time, the fact that the past is different from

0:23.9

the future.

0:25.1

So of course, there is aging in the sense that we are all older now chronologically

0:29.9

than we used to be.

0:31.8

But in the world of biology, there's also aging in the sense that our bodies are changing

0:36.2

as we get older.

0:37.2

In a very uniform, monotonic way, we all had certain qualities when we were babies, we

0:43.8

all have certain features and characteristics when we were elderly, and in between we move

0:48.8

from one to the other in a more or less predictable fashion.

0:52.9

But the interesting thing about aging is that it's not really inevitable.

0:56.8

In a sense, aging is a choice.

0:59.2

It's not a choice that we make as individual organisms.

1:01.9

It's a choice that evolution has made for us.

1:04.8

If we want to have evolutionary progress, then you have certain organisms giving birth

1:09.5

to others, trying new combinations of DNA, occasional mutations.

1:15.2

But then the old ones have to die off.

1:17.6

They have to give way to make room for the new generations.

...

Please login to see the full transcript.

Disclaimer: The podcast and artwork embedded on this page are from Sean Carroll, and are the property of its owner and not affiliated with or endorsed by Tapesearch.

Generated transcripts are the property of Sean Carroll and are distributed freely under the Fair Use doctrine. Transcripts generated by Tapesearch are not guaranteed to be accurate.

Copyright © Tapesearch 2026.