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Lex Fridman Podcast

#153 – Dmitry Korkin: Evolution of Proteins, Viruses, Life, and AI

Lex Fridman Podcast

Lex Fridman

Technology, Society & Culture, Philosophy, Science

4.713.6K Ratings

🗓️ 11 January 2021

⏱️ 138 minutes

🧾️ Download transcript

Summary

Dmitry Korkin is a professor of bioinformatics and computational biology at WPI. Please support this podcast by checking out our sponsors:
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EPISODE LINKS:
Dmitry’s Website: http://korkinlab.org/
Dmitry’s Twitter: https://twitter.com/dmkorkin

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OUTLINE:
Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time.
(00:00) – Introduction
(07:21) – Proteins and the building blocks of life
(14:23) – Spike protein
(21:11) – Coronavirus biological structure explained
(26:09) – Virus mutations
(32:39) – Evolution of proteins
(42:25) – Self-replicating computer programs
(50:02) – Origin of life
(57:34) – Extraterrestrial life in our solar system
(59:31) – Joshua Lederberg
(1:05:30) – Dendral
(1:08:24) – Why did expert systems fail?
(1:10:35) – AlphaFold 2
(1:32:13) – Will AI revolutionize art and music?
(1:39:12) – Multi-protein folding
(1:43:39) – Will AlphaFold 2 result in a Nobel Prize?
(1:46:10) – Will AI be used to engineer deadly viruses?
(2:01:17) – Book recommendations
(2:11:00) – Family
(2:13:38) – A poem in Russian

Transcript

Click on a timestamp to play from that location

0:00.0

The following is a conversation with Munchery Korkin, his second time in the podcast.

0:04.7

He's a professor of bioinformatics and computational biology at WPI, where he specializes in bioinformatics

0:12.0

of complex disease, computational genomics, systems biology, and biomedical data analytics.

0:18.6

He loves biology, he loves computing, plus he is Russian and recites a poem in Russian

0:26.1

at the end of the podcast.

0:27.9

What else could you possibly ask for in this world?

0:31.2

Quick mention of our sponsors.

0:33.0

Brave browser, net sweet business management software, magic spoon, low carb cereal, and

0:40.4

eight sleep self cooling mattress.

0:43.0

So the choice is browsing privacy, business success, healthy diet, or comfortable sleep.

0:49.3

Choose wisely my friends, and if you wish, click the sponsor links below to get a discount

0:54.4

at the support this podcast.

0:56.4

As a side note, let me say that to me, the scientists that did the best, apolitical, impactful,

1:02.3

brilliant work of 2020 are the biologists who study viruses without an agenda, without

1:09.6

much sleep, to be honest, just a pure passion for scientific discovery and exploration of

1:15.8

the mysteries within viruses.

1:18.8

Viruses are both terrifying and beautiful, terrifying because they can threaten the fabric

1:23.5

of human civilization.

1:25.3

It's biological and psychological, beautiful because they give us insights into the nature

1:31.0

of life on earth and perhaps even extraterrestrial life of the not so intelligent variety that

1:38.0

might meet us one day as we explore the habitable planets and moons in our universe.

1:43.8

If you enjoyed this thing, subscribe on YouTube, review it on Apple podcasts, follow on Spotify,

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