151 - Deep Dive into Diltiazem: Pharmaceutics, Medicinal Chemistry, the FDA Orange Book, and More!
HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast
Sean P. Kane, PharmD, BCPS
5 • 644 Ratings
🗓️ 26 July 2022
⏱️ 34 minutes
🧾️ Download transcript
Summary
In this episode, we “deep dive” into diltiazem, describing its most important drug facts, pharmacology and medicinal chemistry, pharmaceutics, AB compatibility, and important medication safety issues.
Key Concepts
- Diltiazem is a non-dihydropyridine calcium channel blocker (CCB). This type of CCB reduces both heart rate and blood pressure whereas dihydropyridine CCBs only reduce blood pressure.
- Diltiazem has numerous dosage forms (IV, immediate release tablets, and extended-release products). Extended-release products are always dosed once or twice daily. Historically there were a significant number of extended-release capsules with a variety of brand names and AB-compatibility. Today, only a few branded products still exist in the US market (Cardizem CD, Cartia XT, Cardizem LA, Tiazac, Taztia XT).
- The FDA Orange Book describes “AB” compatibility, which outlines whether one formulation is therapeutically equivalent to another formulation. Depending on state law, pharmacists can use AB compatibility codes to automatically substitute formulations without notifying the prescriber.
- The numerous dosage forms of diltiazem is a medication safety issue. Remember that immediate release diltiazem is always dosed TID/QID (3-4 times per day) whereas extended-release formulations are always dosed once daily. A twice-daily extended-release product was previously on the market but has since been discontinued.
Transcript
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| 0:00.0 | Welcome to Helix Talk, an educational podcast for healthcare students and providers covering real-life clinical pearls, professional pharmacy topics, and drug therapy discussions. |
| 0:11.0 | This podcast is provided by pharmacists and faculty members at Rosal Franklin University College of Pharmacy. |
| 0:17.0 | This podcast contains general information for educational purposes only. This is not professional |
| 0:22.4 | advice and should not be used in lieu of obtaining advice from a qualified health care provider. |
| 0:27.2 | And now on to the show. Welcome to Helix Talk episode 151. I'm your co-host, Dr. Kane. |
| 0:35.9 | And I'm Dr. Patel. And the title of today's episode is, |
| 0:39.8 | Deep Dive into Deltiasm, Pharmaceuticals, medicinal chemistry, the FDA Orange Book, and more. |
| 0:46.4 | So clearly today we're talking about deltiasm, all things deltiasm, kind of a popery of topics that |
| 0:51.4 | we think the audience will get a lot of value out of all of these |
| 0:54.5 | different aspects of the drug and how it relates to clinical practice. |
| 0:59.9 | And Dr. Kane, if I'm not wrong, this was one of our listener requested topic because they |
| 1:05.9 | wanted to understand the difference between all different formulations of deltiasm that are out there. |
| 1:11.8 | Exactly. And it's actually really confusing. I would say prior to preparing this topic, |
| 1:16.1 | I actually didn't have a full understanding of all of the differences and the nuances for those |
| 1:20.6 | dosage forms. So we will absolutely be covering the confusing state of deltiasm dosage forms, |
| 1:26.7 | but we're also going to go beyond that |
| 1:28.1 | and cover kind of the top 200 drug-esque facts about the drug and a variety of other topics as |
| 1:33.9 | well. |
| 1:34.9 | So kind of kicking us off to discuss the background or the basics of Deltie-A-Azam, you know, |
| 1:41.8 | there are multiple different brand names, but we'll call it cardism for |
| 1:46.7 | right now, and it belongs to a drug category of non-dihydropyridine type of calcium channel |
| 1:53.5 | blockers. As we know, there is two different types. Yeah, and we'll talk more about the medicinal |
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