#138 - Lauren Miller Rogen and Richard Isaacson, M.D.: Alzheimer’s disease prevention—patient and doctor perspectives

The Peter Attia Drive

Peter Attia, MD

Health & Fitness, Medicine, Fitness

4.7 • 7.3K Ratings

🗓️ 23 November 2020

⏱️ 132 minutes

🔗️ Recording | iTunes | RSS

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Summary

Peter is joined by writer, director, actress, and founder of HFC, Lauren Miller Rogen, and previous podcast guest and director of the Alzheimer’s Prevention Clinic at Weill Cornell Medicine and New York-Presbyterian, Dr. Richard Isaacson. In this episode, Lauren tells the heartbreaking story of watching members of her family succumb to Alzheimer’s disease (AD) which motivated her to proactively address her own risk with Richard’s guidance. Richard discusses the various genetic and lifestyle factors that influence the risk of AD and uses Lauren’s unique situation to explain how he diagnoses patients and personalizes care. They go through Lauren’s protocol of preventative measures that have already produced marked results, and end with the uplifting message that one’s genetic predisposition does not seal one's fate.

We discuss:

Lauren’s deep family history of Alzheimer’s disease (3:10);
The influence of genetics, epigenetics, and lifestyle on Alzheimer’s disease risk (13:45);
Lauren’s mother’s disease progression and the enormous stress it causes for family members (24:30);
The various manifestations of Alzheimer’s disease depending on the location of pathology (29:30);
The three stages of Alzheimer's disease (34:45);
Richard’s deep exploration into Lauren’s family history revealing clues about a diagnosis and a roadmap to successful disease mitigation (39:15);
How exercise reduces Alzheimer’s disease risk, and the different risk between males and females (58:00);
Why knowing your APOE status is important, and whether certain people should be wearier of head trauma (1:08:00);
How Richard uses genetic testing to personalize care (1:14:45);
The “ABCs” of Alzheimer’s prevention, lifestyle interventions, and Lauren’s personal protocol for reducing her risk (1:21:45);
Unique treatment for people with the ApoE4 variant (1:36:30);
Richard’s mixed opinion on CBD and THC as a tool for disease prevention (1:40:00);
Cognitive testing procedures, and how Lauren’s tests furthered her commitment to her disease prevention protocol (1:41:45);
The relevance of sense of smell and hearing in Alzheimer’s disease risk and prevention (1:50:00);
The emotional benefit of knowing you have control over your mental and physical health (1:57:30);
HFC—a charitable organization founded by Lauren and Seth (2:00:15); and
More.

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Transcript

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0:00.0	Hey everyone, welcome to the Drive Podcast.
0:13.0	I'm your host, Peter Atia.
0:14.8	This podcast, my website, and my weekly newsletter, all focus on the goal of translating
0:18.7	the science of longevity into something accessible for everyone.
0:22.4	Our goal is to provide the best content in health and wellness, full stop, and we've assembled
0:27.0	a great team of analysts to make this happen.
0:29.4	If you enjoy this podcast, we've created a membership program that brings you far more
0:33.2	in-depth content if you want to take your knowledge of the space to the next level.
0:37.2	At the end of this episode, I'll explain what those benefits are, or if you want to learn
0:41.0	more now, head over to peteratiamd.com forward slash subscribe.
0:46.2	Now, without further delay, here's today's episode.
0:51.1	My guests this week are Lauren Miller-Rogan and Richard Isaacson.
0:56.0	Lauren is an actress, screenwriter, director, but also a friend and patient.
1:00.7	She's the co-founder of Hilarity for Charity or HFC, a national nonprofit organization whose
1:06.9	mission is to care for the families facing disease of Alzheimer's disease, educate them
1:11.6	about living a healthy brain life, and activate the next generation of Alzheimer's advocates.
1:18.2	Richard Isaacson should be a familiar name for some of you as he was a guest on a previous
1:23.2	episode of the drive in late 2018 when we did a deep dive into Alzheimer's disease.
1:29.1	Many of you have requested follow-up podcasts on this topic among them.
1:34.4	This is one.
1:35.4	Richard serves as the director of the Alzheimer's Prevention Clinic at Wile Cornell, New
1:39.7	York Presbyterian Hospital, and is a assistant dean at the office of the faculty of Wile
	...

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