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Lex Fridman Podcast

#133 – Manolis Kellis: Biology of Disease

Lex Fridman Podcast

Lex Fridman

Technology, Society & Culture, Philosophy, Science

4.713.6K Ratings

🗓️ 25 October 2020

⏱️ 160 minutes

🧾️ Download transcript

Summary

Manolis Kellis is a computational biologist at MIT. Please support this podcast by checking out our sponsors:
SEMrush: https://www.semrush.com/partner/lex/ to get a free month of Guru
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BetterHelp: https://betterhelp.com/lex to get 10% off

EPISODE LINKS:
Manolis Website: http://web.mit.edu/manoli/
Manolis Twitter: https://twitter.com/manoliskellis
Manolis YouTube: https://www.youtube.com/channel/UCkKlJ5LHrE3C7fgbnPA5DGA
Manolis Wikipedia: https://en.wikipedia.org/wiki/Manolis_Kellis

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YouTube Clips: https://youtube.com/lexclips

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OUTLINE:
Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time.
00:00 – Introduction
08:05 – Molecular basis for human disease
32:04 – Deadliest diseases
37:47 – Genetic component of diseases
46:38 – Genetic understanding of disease
1:02:25 – Unified theory of human disease
1:08:26 – Genome circuitry
1:33:29 – CRISPR
1:45:06 – Mitochondria
1:53:10 – Future of biology research
2:22:46 – The genetic circuitry of disease

Transcript

Click on a timestamp to play from that location

0:00.0

The following is a conversation with Manoas Kellis, his third time on the podcast.

0:05.3

He is a professor at MIT and head of the MIT Computational Biology Group.

0:11.2

This time, we went deep on the science, biology and genetics.

0:17.0

So this is a bit of an experiment.

0:19.8

Manoas went back and forth between the basics of biology to the latest state of the art and the research.

0:26.4

He's a master at this.

0:28.1

So I just sit back and enjoy the ride.

0:31.0

This conversation happened at 7 a.m., so it's yet another podcast episode after an all-nighter for me.

0:38.2

And once again, since the universe has a sense of humor, this one was a tough one for my brain to keep up,

0:45.3

but I did my best and I never shy away from a good challenge.

0:50.2

Quick mention of e-sponsor followed by some thoughts related to the episode.

0:55.5

First is SCM Rush, the most advanced SEO optimization tool I've ever come across.

1:02.1

I don't like looking at numbers, but someone probably should.

1:05.9

It helps you make good decisions.

1:08.3

Second is pessimist archive.

1:10.6

They're back.

1:11.7

One of my favorite history podcasts on why people resist new things from recorded music to umbrellas,

1:17.8

to cars, chas, coffee and the elevator.

1:22.0

Third is 8th sleep.

1:23.6

A mattress that cools itself, measures heart rate variability, has an app, and has given me yet another reason to look forward to sleep,

1:31.3

including the all-important power nap.

1:34.6

And finally, better help.

...

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