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The Matt Walker Podcast

#117 - Can Creatine & Exercise Overcome Sleep Deprivation?

The Matt Walker Podcast

Dr. Matt Walker

Medicine, Science, Social Sciences, Health & Fitness

4.8995 Ratings

🗓️ 1 December 2025

⏱️ 18 minutes

🧾️ Download transcript

Summary

Matt confronts the systemic failure of sleep deprivation, examining its impact on our biological machinery. When sleep is short, the body's "fuel gauge" dips, impairing mitochondrial function and glucose tolerance. However, he highlights compelling research on two interventions - creatine supplementation and high-intensity interval training. These act as backup generators, offering a physiological buffer to preserve metabolic and executive functions when rest is unavoidably restricted. The ep...

Transcript

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0:00.0

Hi there, it's Matt here and a warm welcome back to the show. And just a quick mention,

0:07.9

you may have heard me speak about the four macros of good sleep, quantity, quality, regularity,

0:15.7

and timing. Working with a group of other scientists, we have produced a free online sleep assessment

0:21.7

that helps you measure the four macros of good sleep and provides a detailed breakdown of

0:29.2

your performance, offers suggested tips for improving areas of weakness. And you can also get more

0:36.6

information about sleep disorders. It's free

0:39.2

and simple to complete within just a few minutes. If you want to do the assessment, just go over to

0:45.4

QQRT.org. Again, that's QQRT.org to complete your free assessment. But coming back today, we're tackling a topic that many

0:58.4

of us struggle with, sleep loss, and more specifically, what the latest science says we can do to

1:05.0

minimize its impact. We all know that not getting enough sleep affects both our brain and body, but what exactly

1:13.4

happens when we're consistently short on sleep? And perhaps more usefully, what can we do about it?

1:21.1

Recent research points to two interventions, creatine supplementation and high-intensity exercise that appear to help

1:30.7

buffer some of the consequences. Think of these as backup generators that kick in when your

1:38.0

main power grid goes down. They won't replace proper sleep, but they can keep essential systems running while you work

1:46.5

toward a better solution. Before we dive into the solutions, let's understand what we're dealing with.

1:53.5

Sleep deprivation isn't just about feeling tired. It's a systemic challenge that touches

1:58.9

multiple biological processes. research has linked chronic sleep

2:04.5

loss to increased risk of various health conditions, cardiovascular issues, metabolic dysfunction,

2:11.6

mood disturbances, and others. It's worth taking seriously, though it's also worth noting

2:17.1

that many of these

2:18.5

associations come from observational studies and individual responses very considerably.

2:25.8

One study examined young, healthy men who had their sleep restricted to four hours per night

...

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