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The Matt Walker Podcast

#105 - Delta Sleep Inducing Peptides

The Matt Walker Podcast

Dr. Matt Walker

Medicine, Science, Social Sciences, Health & Fitness

4.8995 Ratings

🗓️ 18 August 2025

⏱️ 21 minutes

🧾️ Download transcript

Summary

In this episode, Matt delves into the curious and cautionary tale of Delta Sleep-Inducing Peptide (DSIP), once hailed as a potential miracle cure for insomnia. In the 1970s, researchers were on a quest for a single "somnogenic molecule" that could act as the brain's natural sleep switch. A Swiss team believed they had found it, isolating a peptide that appeared to rapidly induce deep, slow-wave sleep when injected into animals. This initial excitement led to bold claims and sparked decades of...

Transcript

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0:00.0

Hi there, it's Matt here and welcome back to the podcast. Today, we're exploring one of

0:08.5

sleep sciences most puzzling stories, the curious case of delta sleep inducing peptide. It's a tale

0:17.1

that spans decades filled with promising discoveries, mysterious contradictions, and a twist

0:23.2

ending that nobody saw coming. Back in the 1970s, several sleep scientists were in many ways

0:31.1

seeking to be treasure hunters searching for the ultimate prize, something they called a sleep molecule. They were looking for a

0:40.8

natural chemical that could make anyone fall into deep sleep instantly. Imagine if you could

0:48.0

bottle up that irresistible feeling when you're so sleepy, you can barely keep your eyes open and then give that to someone

0:56.3

who couldn't sleep. That's exactly what they were hunting for. A team of scientists in Switzerland

1:01.6

claimed they found exactly that. They called it Delta sleep-inducing peptide. The name itself was bold,

1:09.9

like naming a racehorse champion before it ever runs a race.

1:14.2

It sounded like something out of a fairy tale, as if scientists had figured out how to capture

1:19.4

the sandman's magic and put it in a laboratory bottle. But as we'll see, this story is more

1:25.7

about what happens when scientists get swept up

1:29.3

in their excitement and don't ask enough tough questions.

1:33.4

This is a story about promising findings that other scientists couldn't repeat, confusing

1:39.4

results that should have been warning signs, and how the scientific community was slow to admit

1:45.1

they might have been wrong. What followed was a decades-long journey through thrilling

1:51.2

discoveries, puzzling contradictions, and mysterious dead ends. The path from discovery

1:58.5

to disappointment would teach the scientific world important lessons

2:03.3

about the dangers of overconfidence and the complexity of sleep itself.

2:08.9

Our story begins in Basel, Switzerland in 1977. Picture this. It's late at night in a laboratory,

2:16.7

and researchers are doing something quite unusual.

...

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