#066 Dr. Mark Mattson on the Benefits of Stress, Metabolic Switching, Fasting, and Hormesis
FoundMyFitness
Rhonda Patrick, Ph.D.
4.8 • 5.5K Ratings
🗓️ 24 August 2021
⏱️ 140 minutes
🧾️ Download transcript
Summary
Dr. Mark Mattson
Dr. Mark Mattson is a professor of neuroscience at the Johns Hopkins University School of Medicine and the former chief of the Neuroscience Research Laboratory at the National Institute on Aging. He's one of the most cited neuroscientists in the world, with more than 180,000 citations noted in the scientific literature.
Dr. Mattson's work has advanced scientific understanding of brain aging and identified fundamental aspects of neurodegenerative disorders, including Alzheimer’s disease and Parkinson’s disease. His most notable work has focused on how the brain responds to mild stressors, such as those associated with exercise and intermittent fasting.
In this episode, we discuss...
- 00:3:31 - Hormetic stressors drive adaptation and prevent physiological complacency
- 00:13:00 - Intermittent fasting improves health by promoting metabolic switching
- 00:16:49 - Daily time-restricted eating vs 5:2 weekly fasting
- 00:27:44 - A ketogenic diet and intermittent fasting differ in terms of brain effects
- 00:34:23 - Exercising while intermittent fasting exerts additive effects
- 00:52:32 - Plant-based bioactive compounds induce hormetic stress
- 01:10:48 - Severe caloric restriction may compromise muscle mass
- 01:26:25 - Intermittent fasting in young vs. old and in men vs. in women
- 01:35:20 - The effects of cortisol differ during a fast versus chronic stress
- 01:53:36 - Fasting-mimetics like resveratrol and spermidine vs actual fasting
- 02:08:44 - How ketone supplementation may improve brain health
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Transcript
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| 0:00.0 | Hello friends, I'm excited to share a new interview with Dr. Mark Mattson. |
| 0:06.0 | Dr. Mark Mattson is an adjunct professor of neuroscience at the Johns Hopkins University School of Medicine, |
| 0:12.0 | and the former chief of the neuroscience research laboratory at the National Institute on Aging. |
| 0:17.0 | He is one of the most cited neuroscientists in the world, with more than 180,000 citations of his work noted in the scientific literature. |
| 0:26.0 | Dr. Mattson's rigorous work has advanced scientific understanding of brain aging and identified fundamental aspects of age-related neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. |
| 0:39.0 | His most notable contributions, however, have probably been that of his role as the father of hormises and intermittent fasting, for which he is extraordinarily well known. |
| 0:50.0 | At the start of the interview, you'll hear a little bit more about why I was so excited to have this conversation with Dr. Mattson. |
| 0:58.0 | We're trying something new today with this episode, and releasing the interview audio here first, exclusively on the Found My Fitness Podcast feed. |
| 1:06.0 | For those of you listening who also enjoy our in-depth video interviews, don't worry, we plan to release the full annotated video version of the interview very soon. |
| 1:15.0 | As many of you already know, the post-production work that goes into our videos is quite intense, and we just couldn't wait to share this conversation with you. |
| 1:23.0 | On to the important stuff. In this episode, Dr. Mattson and I discuss, how Hormetic Stressors Drive Adaptation and Prevent Physiological Complacency, |
| 1:34.0 | how Intermittent Fasting Improves Health by Promoting Metabolic Switching, how Daily Time Restricted Eating and 5-2 Weekly Fasting Compare, |
| 1:43.0 | how A Ketogenic Diet and Intermittent Fasting Differ in Terms of Brain Effects, how Exercising While Intermittent Fasting Exerts Additive Effects, |
| 1:53.0 | how Plant-Based Biolactive Compounds Induce Hormetic Stress, how severe Chaloric Restriction may harm the body and compromise muscle mass, |
| 2:03.0 | how older adults, children, women, and pregnant women respond to Intermittent Fasting, |
| 2:09.0 | how the effects of cortisol differ during a fast versus chronic uncontrollable stress, |
| 2:14.0 | how the effects of fasting mimetics like Resvera Chal are spirmidine compared with actual fasting, |
| 2:20.0 | and how ketone supplementation may improve brain health. |
| 2:25.0 | A couple of quick reminders before we get to the podcast. |
| 2:28.0 | If you ever find yourself wanting to dive a little deeper on an episode you listen to here, then you should subscribe to my newsletter. |
| 2:34.0 | It's completely free and we respect your inbox. I only send it out when we have new, fully researched topic pages, |
| 2:41.0 | exciting upcoming podcast episodes, or updates on new research on some of my favorite topics. |
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