057 - Kicking acid, taking names ... the story of PPI use and abuse
HelixTalk - Rosalind Franklin University's College of Pharmacy Podcast
Sean P. Kane, PharmD, BCPS
5 • 644 Ratings
🗓️ 28 February 2017
⏱️ 29 minutes
🧾️ Download transcript
Summary
In this episode, we discuss the overuse of proton pump inhibitor (PPI) therapy and several concerns regarding chronic use of this medication class, including hypomagnesemia, fracture risk, low seurm B12 levels, anemias, and increased risk of certain infections.
Transcript
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| 0:00.0 | Welcome to Helix Talk, an educational podcast for healthcare students and providers covering real-life clinical pearls, professional pharmacy topics, and drug therapy discussions. |
| 0:11.0 | This podcast is provided by pharmacists and faculty members at Rosal Franklin University College of Pharmacy. |
| 0:17.0 | This podcast contains general information for educational purposes only. This is not |
| 0:22.0 | professional advice and should not be used in lieu of obtaining advice from a qualified health |
| 0:26.3 | care provider. And now on to the show. Welcome to Helix Talk episode 57. I'm your co-host |
| 0:34.0 | Dr. Kame. I'm Dr. Schumann. And I'm Dr. Patel. And so today, I'm going to kind of take the lead a little bit differently this time, |
| 0:40.8 | and we're bringing up the topic of PPI, or as we like to say, |
| 0:43.9 | kicking acid, taking names, the story of PPI use or proton pump-inheber use. |
| 0:49.1 | And perhaps not even PPI use, but PPI abuse, right? |
| 0:52.3 | Yeah, exactly. And that's going to be something to really look at is this is one I think it's been coming |
| 0:56.2 | up in the news from time to time over the last few years and different FDA warnings |
| 1:00.6 | come about a little, you know, some lot of information and concern about these medications. |
| 1:04.4 | Well, let's jump into some of the pharmacology of the PPI as just to give a good background |
| 1:07.8 | on what these medications are doing, that kind of informs other topics |
| 1:12.0 | that we'll be talking about. Hopefully, as the listeners know, these are hydrogen potassium, |
| 1:15.8 | ATP, exchanger, inhibitors. So they're blocking the stomach's ability to secrete hydrogen ions |
| 1:21.8 | into the stomach in the form of stomach acid. And it's actually available to treat a lot of different GI conditions, mainly GERD, |
| 1:30.2 | Erosophagitis, you know, gastritis, ulcers, some of those secretory conditions such as |
| 1:36.4 | Zolinger-Allenson syndrome in which the GI cells, GI tract produces more acid than needed. |
| 1:42.2 | And it's also part of the combination regimen to treat |
| 1:46.1 | the H. Pilari infection. And these are ones, and I would love to hear Dr. Kane's comments, |
| 1:51.9 | but they seem to get a lot of use in individuals getting admitted to the hospital, you know, |
... |
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