#040 Dr. Eric Verdin on Ketogenic Diet Longevity, Beta-Hydroxybutyrate & HDAC Inhibitors

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Rhonda Patrick, Ph.D.

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4.8 • 5.5K Ratings

🗓️ 13 December 2017

⏱️ 63 minutes

🔗️ Recording | iTunes | RSS

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Summary

Eric M. Verdin

Eric M. Verdin, M.D. is the fifth president and chief executive officer of the Buck Institute for Research on Aging and is a professor of Medicine at UCSF.

Dr. Verdin's laboratory focuses on the role of epigenetic regulators in the aging process, the role of metabolism and diet in aging and on the chronic diseases of aging, including Alzheimer’s, proteins that play a central role in linking caloric restriction to increased healthspan, and more recently a topic near and dear to many of you, ketogenesis. He's held faculty positions at the University of Brussels, the NIH and the Picower Institute for Medical Research.

In this episode, you'll discover:

00:00 - Introduction
07:32 - Interventions to prolong lifespan
10:42 - The role of insulin pathways in aging
16:25 - HDAC inhibition by ketones
27:52 - Protein activates mTOR & IGF-1
30:28 - PPAR-alpha activation facilitates benefits of a ketogenic diet
35:28 - What biomarkers can predict aging?
39:38 - Cellular NAD+ levels decrease with age
52:47 - Ketogenic diet safety
56:07 - Intermittent fasting as an alternative to a keto diet

If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/69

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Transcript

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0:00.0	Hello everyone! Today's podcast feature is Dr. Eric Verdin.
0:04.0	Eric's laboratory focuses on the role of epigenetic regulators in the aging process,
0:08.1	the role of metabolism and diet in aging and on chronic diseases of aging including
0:12.4	Alzheimer's disease, proteins that play a central role in linking caloric restriction to
0:16.8	increased health span, and also, more recently, a topic near and dear to many of you,
0:21.9	ketogenesis. He's helped faculty positions at the University of Brussels, the NIH,
0:27.2	the PCOWER Institute for Medical Research. He is a professor of medicine at UCSF and is currently
0:32.2	the fifth president and chief executive officer of the BUCK Institute for Research on Aging.
0:37.2	In this podcast, we talk broadly about many interesting areas of inquiry in aging,
0:41.3	especially the areas that Dr. Verdin and his colleagues are involved in. But of special interest
0:46.0	is his lab's recent publication on a cyclic ketogenic diet, and in other words, a version of
0:50.7	the ketogenic diet where they rotate a normal diet and a ketogenic diet periodically.
0:55.8	Particularly interesting is that it reduced midlife mortality and also memory decline.
1:00.1	We also discussed some of the current research including Dr. Verdin's regarding the role of NAD
1:04.4	plus in the aging process. A topic made especially popular due to the research surrounding
1:08.7	nicotinamide ribosite, a precursor to NAD plus, as a potential anti-aging supplement.
1:14.4	A few words about this episode, this podcast I would rate as a six or maybe seven in terms of
1:19.0	technical difficulty, and in other words, relative to my other podcast, there are some that have
1:23.8	greater technical depth. But there could be a few stumbling blocks in this one too, so let's talk
1:28.4	about those. The three stumbling blocks for this podcast, if there are any, are probably the
1:33.2	discussions surrounding MTOR, PPAR alpha, and a family of enzymes known as HDAX, or histone
1:40.0	deacetylases, and the compounds in enzymes that inhibit them, which are known as HDAX inhibitors.
	...

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