#02 - Rhonda Patrick, Ph.D.: the performance and longevity paradox of IGF-1, ketogenic diets and genetics, the health benefits of sauna, NAD+, and more

The Peter Attia Drive

Peter Attia, MD

Health & Fitness, Medicine, Fitness

4.7 • 7.3K Ratings

🗓️ 2 July 2018

⏱️ 110 minutes

🔗️ Recording | iTunes | RSS

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Summary

Rhonda and I go on a Nerd Safari into the jungle of health, nutrition, fitness, performance, and longevity. We visit IGF-1 and whether there’s a tradeoff of having high or low levels. We discuss the PPARs (receptor proteins) and genetic polymorphisms. Does Rhonda think there’s any benefit in a NAD+ booster for health and longevity? Can saunas lower the risk of heart disease, dementia, and all-cause mortality?

Rhonda is a wealth of knowledge on so many topics and was the perfect companion to dig into so many fun topics in this episode. She puts a ton of thought into her research and it really shows in this conversation.

We discuss:

What Rhonda believes differently today than she did a few years ago [5:40];
The paradox of GH/IGF-1 in performance and longevity [21:00];
The role of PPAR in fat metabolism and ketogenic diets [23:00];
The possible genetic explanations for why some patients don’t respond well to a ketogenic diet [31:00];
The health benefits of heat and cold exposure [1:12:30];
NAD+ [1:32:45];
And more.

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Transcript

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0:00.0	Hey everyone, welcome to the Peter Atia Drive. I'm your host, Peter Atia.
0:10.0	The drive is a result of my hunger for optimizing performance, health, longevity, critical thinking,
0:15.7	along with a few other obsessions I've gathered along the way.
0:18.6	I've spent the last several years working with some of the most successful top performing
0:21.9	individuals in the world, and this podcast is my attempt to synthesize what I've learned
0:26.1	along the way to help you with a higher quality, more fulfilling life.
0:30.2	If you enjoy this podcast, you can find more information on today's episode and other
0:34.1	topics at peteratiamd.com.
0:42.0	Welcome to the Peter Atia Drive. In this episode, which I know is long anticipated, I spoke
0:47.4	with Dr. Ronda Patrick from Found My Fitness. I suspect many of you listening to this,
0:53.2	know everything about Ronda and have been fans of her for a really long period of time
0:57.0	on the off-chance there's anybody listening who doesn't know who Ronda is. I suspect by
1:01.4	the end of this discussion, you will also become a huge fan of hers and her podcast, which
1:06.8	is exceptional. I've known Ronda for quite a while, and despite the fact that we both consider
1:12.7	San Diego home, we've just been busy enough that we just haven't had a chance to sit down
1:17.1	together in quite a while. This discussion was long overdue, and it was sort of funny
1:21.7	because as soon as Ronda walked in, we just jumped right into a really interesting discussion,
1:26.8	and then 10 minutes in, I thought, we should probably start recording because this is interesting
1:30.3	stuff. We did. Similarly, when the discussion finally ended, we sat around for another
1:35.2	20 minutes talking about a bunch of stuff that I found myself thinking, God, I wish we
1:38.8	were still recording this because it's super interesting. That's just basically to say,
1:42.0	I suspect Ronda and I will speak again at some point soon, so don't worry if all of your
	...

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